Italian Chileans (Italian: italo-cileni; Spanish: ítalo-chilenos) are Chilean-born citizens who are fully or partially of Italian descent, whose ancestors were Italians who emigrated to Chile during the Italian diaspora, or Italian-born people in Chile. It is estimated that about 600,000 Chileans are of full or partial Italian ancestry, while Italians by birth in Chile are about 52,000. In Southern Chile, there were state-conducted Italian immigrant programs though they were not as massive as the German and Croatian immigrant programs. Families settled especially in Capitán Pastene, Angol, Lumaco, and Temuco but also in Valparaiso, Concepción, Chillán, Valdivia, and Osorno. One of the notable Italian influences in Chile is, for example, the sizable number of Italian surnames of a proportion of Chilean politicians, businessmen, and intellectuals, many of whom intermarried into the Castilian-Basque elites.

Italian Chileans, along with French Chileans, contributed to the development, cultivation and ownership of the world-famous Chilean wines from haciendas in the Central Valley, since the first wave of Italians arrived in colonial Chile in the early 19th century.

Italians in immigration to Chile have been present since the arrival of the first Spaniards into the country, such as Captain Giovanni Battista Pastene who helped Pedro de Valdivia's expedition. Thence, with akin Latin culture, Italians have helped forge the nation, with architects (Gioacchino Toesca), painters (Camilo Mori), businessmen (Anacleto Angelini), economists (Vittorio Corbo) and statesmen (Arturo Alessandri).

Since Italian immigration was never massive or organized, the only case of concerted immigration appeared in the town of Capitán Pastene, in the Araucanía Region of southern Chile, where in 1904, 23 families from Emilia-Romagna were left at their own device after being wrongfully enticed to the "riches" of Chile. Today, this small town celebrates a renaissance of their Italic heritage.

Italian emigration in Chile was limited to a few tens of Italians during the centuries of the Spanish colony.

After independence, the Chilean government encouraged European emigration but with less success than in neighboring Argentina, given the markedly lower number of foreigners present in Chile (in 1907 the presence of foreigners in Chile was 4.5% of the population, while in Argentina it was 78%).

However, there was a substantial flow of migration from Liguria to the area of Valparaíso, which came to control 70% of the city. These immigrants founded the "Body of Fire" (called "Cristobal Colon") of the city and its "Italian School," whose building the government of Chile has declared a National Historic Monument (Spanish: "Monumento Histórico Nacional").

At the end of the 19th century, many Italian merchants were rooted in the northern part of Arica, where they began exploiting the rich mines of saltpetre. Meanwhile, many Italian families settled in the capital Santiago, Concepción and Punta Arenas.