The Myzeqe (Albanian: [myzɛˈcɛ]; Albanian definite form: Myzeqeja; Aromanian: Muzachia) is a plain in the Western Lowlands of Albania. The Myzeqe is the largest and widest plain, measured by area, in the Lowlands.

The Myzeqe plain is a large alluvial plain traversed by three main rivers, the Shkumbin, Seman and Vjosë. The Vjosë gives a rough approximation of the southern extent of the Myzeqe, while the Shkumbin is roughly its northern extent. Administratively, the region falls mainly within Lushnjë and Fier District.

Other terms like Myzeqeja e Vogël (Small Myzeqe), Myzeqeja e Beratit (Berat's Myzeqe), or Myzeqeja e Vlorës (Vlora's Myzeqe) are used to point respectively to the Fier part of the region, and to tiny parts that fall into the adjacent districts of Berat and Vlorë. It stretches 65 km north–south and 50 km east–west, with a total area of around 1350 square kilometers. The oldest population to inhabit the Myzeqe plain are the Albanian tribe of the Lalë.

The name of the region comes from the Medieval times, it is named after the ruling family of Muzaka (1280 – 1600) which possessed the area. The toponym is first recorded as Musachia in 1417.

In antiquity, the Greek colony of Apollonia was founded near the coast. The site of Apollonia lay on the territory of the Taulantii, a cluster of Illyrian tribes that remained closely involved with the settlement for centuries and lived alongside the Greek colonists. The Taulantii controlled much of the plain of Myzeqe in classical antiquity.

In the Middle Ages, and was ruled by various Albanian noble families including the Skuraj and Muzaka families. At various times it was included in the Byzantine Empire and the Bulgarian Empire, often with the local ruling families serving as vassals to the rulers of the realm. Plenty of Slavic language toponyms are present in Myzeqe.

In the late 13th century the area came under the rule of the officially Catholic and French-tied Angevin Kingdom of Albania. At first, relations were bad between the kingdom's rulers and the local nobility, and at times the nobility, such Gjin Muzaka, collaborated with the Byzantines against the kingdom. However, over time the local house of Muzaka came to view the Angevin royal family of Albania as their allies and protectors especially as the threat of Serbian expansion increased, and became more loyal to them. They were given titles as the region became influenced by the Western style of feudalism. At the same time, the Angevins allowed the local rulers to keep their Orthodox faith. In 1318, Andrea I Muzaka became the first ever Orthodox Albanian to be the head general of the kingdom's army, and the Muzakas played a role in King Charles' battles against the Serbs. In other conflicts, the Muzakas sided again with Byzantium, with Andrea II Muzaka being honored for his service to the Byzantine cause in 1335 after defeating a Serbian army in the Pelister mountains near Bitola. The remnants of Byzantine control over the region collapsed during the 1341-1347 Byzantine civil war, creating an opportunity which was taken by the Serbian ruler Stefan Dushan, at the expense of the Kingdom of Albania.

In the middle of the 14th century, the region was conquered by Stefan Dushan of Serbia, but it did not take long for the Serbian Empire's control over the region to fragment as the local families reasserted control. Four decades later, the Battle of Savra (as one of the plains of Myzeqe was known in the Middle Ages) marked the ascendancy of the Ottoman Empire in the region. In the 15th century, the Muzaka family and other local Albanian lords joined Skanderbeg's League of Lezhë to try to contain the growing dominance of the Ottomans, but after a long conflict, Myzeqe as well as wider Albania ended up decisively under Ottoman rule until the early 20th century. Some of the local Albanian rulers as well as some of the population ended up fleeing to foreign countries, but some of the rulers stayed and became integrated into the Ottoman power apparatus.