A globular cluster is a spheroidal conglomeration of stars that is bound together by gravity, with a higher concentration of stars towards its center. It can contain anywhere from tens of thousands to many millions of member stars, all orbiting in a stable, compact formation. Globular clusters are similar in form to dwarf spheroidal galaxies, and though globular clusters were long held to be the more luminous of the two, discoveries of outliers had made the distinction between the two less clear by the early 21st century. Their name is derived from Latin globulus (small sphere). Globular clusters are occasionally known simply as "globulars".

Although one globular cluster, Omega Centauri, was observed in antiquity and long thought to be a star, recognition of the clusters' true nature came with the advent of telescopes in the 17th century. In early telescopic observations, globular clusters appeared as fuzzy blobs, leading French astronomer Charles Messier to include many of them in his catalog of astronomical objects that he thought could be mistaken for comets. Using larger telescopes, 18th-century astronomers recognized that globular clusters are groups of many individual stars. Early in the 20th century the distribution of globular clusters in the sky was some of the first evidence that the Sun is far from the center of the Milky Way.

Globular clusters are found in nearly all galaxies. In spiral galaxies like the Milky Way, they are mostly found in the outer spheroidal part of the galaxy – the galactic halo. They are the largest and most massive type of star cluster, tending to be older, denser, and composed of lower abundances of heavy elements than open clusters, which are generally found in the disks of spiral galaxies. The Milky Way has more than 150 known globulars, and there may be many more.

Both the origin of globular clusters and their role in galactic evolution are unclear. Some are among the oldest objects in their galaxies and even the universe, constraining estimates of the universe's age. Star clusters were formerly thought to consist of stars that all formed at the same time from one star-forming nebula, but nearly all globular clusters contain stars that formed at different times, or that have differing compositions. Some clusters may have had multiple episodes of star formation, and some may be remnants of smaller galaxies captured by larger galaxies.

The first known globular cluster, now called M 22, was discovered in 1665 by Abraham Ihle, a German amateur astronomer. The cluster Omega Centauri, easily visible in the southern sky with the naked eye, was known to ancient astronomers like Ptolemy as a star, but was reclassified as a nebula by Edmond Halley in 1677, then finally as a globular cluster in the early 19th century by John Herschel. The French astronomer Abbé Lacaille listed NGC 104, NGC 4833, M 55, M 69, and NGC 6397 in his 1751–1752 catalogue. The low resolution of early telescopes prevented individual stars in a cluster from being visually separated until Charles Messier observed M 4 in 1764.

When William Herschel began his comprehensive survey of the sky using large telescopes in 1782, there were 34 known globular clusters. Herschel discovered another 36 and was the first to resolve virtually all of them into stars. He coined the term globular cluster in his Catalogue of a Second Thousand New Nebulae and Clusters of Stars (1789). In 1914, Harlow Shapley began a series of studies of globular clusters, published across about forty scientific papers. He examined the clusters' RR Lyrae variables (stars which he assumed were Cepheid variables) and used their luminosity and period of variability to estimate the distances to the clusters. RR Lyrae variables were later found to be fainter than Cepheid variables, causing Shapley to overestimate the distances.

A large majority of the Milky Way's globular clusters are found in the halo around the galactic core. In 1918, Shapley used this strongly asymmetrical distribution to determine the overall dimensions of the galaxy. Assuming a roughly spherical distribution of globular clusters around the galaxy's center, he used the positions of the clusters to estimate the position of the Sun relative to the Galactic Center. He correctly concluded that the Milky Way's center is in the Sagittarius constellation and not near the Earth. He overestimated the distance, finding typical globular cluster distances of 10–30 kiloparsecs (33,000–98,000 ly); the modern distance to the Galactic Center is roughly 8.5 kiloparsecs (28,000 ly). Shapley's measurements indicated the Sun is relatively far from the center of the galaxy, contrary to what had been inferred from the observed uniform distribution of ordinary stars. In reality most ordinary stars lie within the galaxy's disk and are thus obscured by gas and dust in the disk, whereas globular clusters lie outside the disk and can be seen at much greater distances.

The count of known globular clusters in the Milky Way has continued to increase, reaching 83 in 1915, 93 in 1930, 97 by 1947, and 157 in 2010. The number of known globular clusters in the Milky Way reached 158 by the end of 2010, according to the European Southern Observatory, before two new globular clusters were discovered as part of the ESO's VISTA (Visible and Infrared Survey Telescope for Astronomy) infrared survey, known as Variables in the Vía Láctea (VVV) survey, bringing the total to 160 known globular clusters. The two discovered by VISTA in 2011 are named VVV CL001 and VVV CL002.