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In organic chemistry, polyenes are polyunsaturated organic compounds that contain multiple carbon–carbon double bonds (C=C).[1][2] Some sources consider dienes to be polyenes,[3] whereas others require polyenes to contain three carbon–carbon double bonds (trienes) or more.[4]

Conjugated polyenes contain a conjugated system of alternating single and double carbon–carbon bonds, with characteristic optical properties.

The following polyenes are used as antimycotics for humans: amphotericin B, nystatin, candicidin, pimaricin, methyl partricin, and trichomycin.[5]

Optical properties

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Some polyenes are brightly colored, an otherwise rare property for a hydrocarbon. Normally alkenes absorb in the ultraviolet region of a spectrum, but the absorption energy state of polyenes with numerous conjugated double bonds can be lowered such that they enter the visible region of the spectrum, resulting in compounds which are coloured (because they contain a chromophore). Thus many natural dyes contain linear polyenes.

Chemical and electrical properties

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Polyenes tend to be more reactive than simpler alkenes. For example, polyene-containing triglycerides degrade in atmospheric oxygen via the process of rancidification and drying. Polyacetylene exhibits high electrical conductivity in air.. Most conductive polymers are polyenes, and many have conjugated structures.

Occurrence

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A few fatty acids are polyenes. Another class of important polyenes are polyene antimycotics.[6]

See also

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References

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Polyene

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A polyene is an consisting of a linear chain of carbon atoms connected by alternating single and double bonds, forming a with delocalized π-electrons, typically involving three or more double bonds. These molecules exhibit unique electronic properties due to the extended conjugation, which allows for efficient delocalization of electrons across the chain, influencing their reactivity and spectroscopic behavior. Polyenes are ubiquitous in nature and play critical roles in biological systems, such as serving as pigments and antioxidants in plants and animals. For instance, carotenoids like beta-carotene and lycopene are polyenes responsible for the vibrant colors in fruits and vegetables, while retinal, a derivative of vitamin A, functions as the chromophore in visual phototransduction. In chemistry, polyenes are studied for their involvement in pericyclic reactions, molecular orbital theory, and as models for understanding conjugation effects in larger systems like conducting polymers. A specialized subclass of polyenes, known as polyene or polyene antifungals, features a large macrocyclic ring with conjugated double bonds and is produced by soil bacteria such as species. These compounds, including amphotericin B and nystatin, exhibit potent antifungal activity by binding to in fungal cell membranes, forming pores that disrupt membrane integrity and lead to . Despite their efficacy, their clinical use is limited by toxicity, prompting ongoing research into derivatives with improved safety profiles.

Definition and Structure

General Definition

Polyenes are organic compounds containing two or more carbon-carbon s, typically arranged in an alternating pattern that often results in conjugation. This structural feature sets polyenes apart from monoenes, which possess only a single double bond, and polyynes, which incorporate multiple triple bonds in their carbon backbone. The concept of polyenes gained prominence in during the early 20th century, particularly through studies of pigments in biological systems. Researchers like elucidated the polyene structures of these pigments in the 1930s, highlighting their role in processes such as vision and . The simplest polyene is 1,3-butadiene, a four-carbon with two conjugated double bonds, first isolated in 1886 from the of . This compound exemplifies the foundational chemistry of polyenes and serves as a model for understanding their conjugated systems.

Molecular Structure and Conjugation

Polyenes are characterized by a conjugated π-electron system, consisting of alternating single σ bonds and double π bonds along a carbon chain. This arrangement enables the overlap of adjacent p-orbitals, resulting in delocalization of π electrons across multiple atoms rather than localization to individual bonds. Such delocalization imparts partial double-bond character to the interconnecting single bonds and enhances molecular stability through . For linear, unsubstituted polyenes, the general molecular formula is \ceCnHn+2\ce{C_nH_{n+2}}, where nn represents the number of carbon atoms and is typically even to accommodate terminal methylene groups (\ce−CH2−\ce{-CH2-}) and an equal number of conjugated double bonds. This formula reflects the nature of these chains, with hydrogen atoms saturating the ends and sides. Examples include (n=4n = 4, \ceC4H6\ce{C4H6}) and hexatriene (n=6n = 6, \ceC6H8\ce{C6H8}). Nomenclature for polyenes follows IUPAC conventions for alkenes, extended to multiple double bonds by indicating their positions with the lowest possible numbers and specifying stereochemistry using the E/Z system. The E configuration denotes trans geometry (higher-priority groups on opposite sides of the double bond), while Z indicates cis (same side). For instance, hexa-2,4-diene is named (2E,4Z)-hexa-2,4-diene when the double bond at position 2 is trans and at position 4 is cis, based on Cahn-Ingold-Prelog priority rules for substituents. In terms of structural features, short linear polyenes maintain a nearly planar conformation, particularly in the s-trans arrangement around single bonds, to optimize π-orbital overlap and conjugation. However, longer chains experience steric hindrance from hydrogen-hydrogen interactions across the chain, causing twists around the C-C single bonds and deviation from planarity. This twisting disrupts full delocalization in extended systems. Polyenes are further described by structures, which depict shifted positions of π bonds (e.g., in 1,3-butadiene, two equivalent forms with localized double bonds), highlighting the delocalization. Qualitatively, this conjugation narrows the HOMO-LUMO gap relative to isolated alkenes, as the extended π system raises the highest occupied (HOMO) and lowers the lowest unoccupied (LUMO), with the gap diminishing as chain length increases.

Physical Properties

Optical Properties

Polyenes exhibit characteristic ultraviolet-visible (UV-Vis) absorption due to their extended π-conjugation, which allows π-electrons to transition from the highest occupied (HOMO) to the lowest unoccupied (LUMO) upon absorbing . As the length of the increases—measured by the number of alternating double bonds—the energy gap between HOMO and LUMO decreases, resulting in a bathochromic shift where absorption maxima move to longer wavelengths. For instance, short polyenes like absorb in the UV region around 217 nm, while longer ones extend into the . This behavior is often modeled using the particle-in-a-box approximation for the delocalized π-electrons confined along the conjugated chain of effective length LL. The quantized energy levels are given by En=n2h28mL2,E_n = \frac{n^2 h^2}{8 m L^2}, where nn is the , hh is Planck's constant, and mm is the ; the transition energy ΔE=En+1−En\Delta E = E_{n+1} - E_n decreases with increasing LL, predicting the observed bathochromic shift. This simple model provides qualitative insights into polyene spectra, though it neglects electron-electron interactions and chain-end effects for more precise calculations. Longer polyenes, such as , display weak primarily from the strongly allowed S2→S0S_2 \to S_0 transition in the visible region, with lifetimes on the order of picoseconds, while the lower-lying S1S_1 state is optically dark and contributes minimally to emission. from the has been observed in carotenoids like , occurring at low temperatures with energies around 88 kJ/mol, indicating from excited singlets. These emission properties arise from the polyene's conjugated backbone, which facilitates rapid and limits radiative decay from lower excited states. The visible absorption of polyenes is responsible for the , orange, and hues observed in natural pigments, as they selectively absorb -green light and transmit or reflect longer wavelengths; , for example, provide these colors in fruits, flowers, and bird feathers. A representative example is , a polyene with 11 conjugated double bonds, which has absorption maxima around 450 nm in the blue region, appearing orange to the .

Electrical Properties

Polyenes display semiconducting characteristics arising from their extended π-conjugated systems, which facilitate delocalization along the molecular . In short-chain polyenes, the wide renders them insulating, but as the conjugation length increases—measured by the number of repeating units N—the narrows significantly, shifting the material toward semiconducting behavior. This reduction follows an empirical relation ΔE ≈ a + b/N, where a represents the limiting for infinite chains and b is a fitting , with theoretical and experimental studies confirming a decrease from over 3 eV in short oligomers to approximately 1.8 eV in . Undoped polyenes exhibit low electrical conductivity, typically on the order of 10^{-9} to 10^{-5} S cm^{-1}, due to the limited number of intrinsic charge carriers. However, doping—through oxidation or reduction—introduces charge carriers such as polarons or bipolarons, dramatically enhancing conductivity. The electrical conductivity σ is described by the relation σ = n e μ, where n denotes the carrier , e the , and μ the charge carrier mobility; in highly doped , this yields values up to 10^5 S cm^{-1} or higher, approaching metallic levels and establishing polyacetylene as a benchmark conducting . Polyenes also form key components in , where their tunable electronic structure supports applications in field-effect transistors and solar cells. The properties of polyenes stem from the pronounced of their π-bonds, which allows greater displacement under an applied compared to saturated hydrocarbons. This results in a (ε_r) typically ranging from 2 to 4, higher than the ~2.0 for alkanes, with conjugation enhancing the overall response; for , model calculations indicate ε_r ≈ 1.2 to 3 depending on the conformation and environment. To probe these electrical properties, is widely employed on polyene thin films, revealing potentials that inform electrochemical doping thresholds and charge injection barriers. For instance, films display a formal of +0.65 V versus the during oxidative doping processes. This technique highlights the reversible in conjugated systems, correlating with their semiconducting band gaps—though optical aspects are covered separately.

Chemical Properties

Reactivity

Polyenes exhibit pronounced reactivity arising from their extended conjugated π-electron systems, which facilitate electrophilic additions and pericyclic processes. The in the conjugated double bonds renders polyenes susceptible to reactions, particularly the Diels-Alder reaction, a concerted [4+2] cycloaddition between the polyene acting as a 1,3-diene and an electron-deficient dienophile. This stereospecific reaction proceeds suprafacially and is thermally allowed under orbital symmetry conservation, yielding derivatives with retained from the reactants. A canonical example is the reaction of 1,3-butadiene with , forming as the product, which exemplifies the utility of polyenes in constructing six-membered rings. Beyond cycloadditions, polyenes participate in pericyclic electrocyclic reactions, where the undergoes ring closure or opening in a stereospecific manner governed by the Woodward-Hoffmann rules. These rules, derived from frontier analysis, dictate that thermal electrocyclic reactions of polyenes with 4n π electrons (e.g., 1,3-butadiene systems) proceed via conrotatory motion, while those with 4n+2 π electrons (e.g., 1,3,5-hexatriene) favor disrotatory motion to maintain orbital symmetry. Photochemical conditions invert this stereochemistry, enabling disrotatory closure for 4n systems and conrotatory for 4n+2 under UV irradiation. Such transformations are pivotal in converting linear polyenes to cyclic structures, as seen in the thermal disrotatory cyclization of (Z)-1,3,5-hexatriene to 5,6-disubstituted-1,3-cyclohexadiene. The allylic positions in polyenes are particularly vulnerable to oxidation due to weakened C-H bonds adjacent to the , promoting radical abstraction and chain propagation. In carotenoid polyenes, peroxyl radicals readily abstract allylic hydrogens (e.g., at C-4 or C-4' in ), generating resonance-stabilized allylic radicals that initiate oxidative degradation of the . This sensitivity is enhanced in polyenes with unsubstituted allylic sites, leading to faster initial oxidation rates compared to those with protective functional groups, such as oxygenated derivatives like . Polyenes also serve as monomers in reactions, notably , where catalysts facilitate the redistribution of double bonds to form extended conjugated polymers. In acyclic metathesis (ADMET), linear conjugated polyenes like 1,ω-dienes undergo stepwise insertion and elimination, yielding high-molecular-weight polyenes with preserved conjugation. This process is complicated by η³-allyl intermediates but enables the synthesis of materials from renewable sources such as or polyunsaturated fatty acids. A notable specific reaction is the [4+2] cycloaddition of to conjugated polyenes, forming 1,4-endoperoxides as stable adducts. This proceeds via a perepoxide intermediate, where the attacks the electron-rich terminus, followed by closure to the bridge; the reaction is regioselective and stereospecific, often yielding cis-endoperoxides from s-cis dienes.

Stability and Degradation

Polyenes exhibit varying degrees of thermal stability depending on chain length, with shorter polyenes generally maintaining structural integrity at elevated temperatures, while longer conjugated systems, such as those in , are more susceptible to cis-trans above 100°C. This isomerization arises from the rotational barriers around single bonds in the polyene backbone, which decrease with increasing conjugation length, allowing to induce geometric changes that disrupt the all-trans configuration predominant in stable forms. For instance, in , a representative long-chain polyene with 11 conjugated double bonds, exposure to temperatures of 100–130°C during processing leads to significant increases in cis-isomer content, correlating with reduced stability and potential degradation pathways. Photodegradation of polyenes primarily occurs through UV-induced bond cleavage, initiated by radical mechanisms that target the extended π-system. Absorption of UV light excites electrons in the polyene , leading to the formation of reactive species such as or direct radical intermediates, which propagate chain reactions resulting in scission of double bonds and formation of shorter apo-carotenoids. In carotenoids, this process is oxygen-dependent in many cases, with quantum yields for increasing in the presence of O₂, as peroxyl radicals add to the conjugated chain, causing bleaching and loss of color via disruption of the polyene structure. Oxidative degradation in polyenes proceeds via auto-oxidation, particularly at allylic hydrogens adjacent to the double bonds, where by peroxyl radicals generates resonance-stabilized allylic radicals that facilitate chain scission and breakdown. This mechanism is prominent in unsaturated systems like , where the reactive allylic positions (e.g., at C-4 in ) enable rapid propagation, leading to products such as epoxides and carbonyl fragments while diminishing the extended conjugation. The process accelerates under aerobic conditions, contributing to overall instability by cleaving the polyene backbone into non-conjugated segments. To mitigate these degradation pathways, stabilization strategies often incorporate antioxidants, such as (α-tocopherol), which scavenge free radicals and prevent auto-oxidation in systems. In biofortified crops, elevated levels have been shown to extend the stability of β-carotene by inhibiting oxidative attack, demonstrating a synergistic protective effect on the polyene chain. For example, β-carotene in air-exposed storage without such protection exhibits a of approximately 6 weeks, highlighting the rapid degradation under ambient conditions and the value of interventions for preserving polyene integrity.

Synthesis

Common Synthetic Methods

The construction of polyene chains typically relies on iterative carbon-carbon bond-forming reactions that extend conjugation while maintaining stereochemical integrity. Laboratory methods emphasize olefination and transition-metal-catalyzed couplings, which offer versatility in handling functional groups and achieving high yields. These approaches have been refined over decades to address the inherent instability of polyenes during synthesis. The remains a cornerstone for polyene assembly, involving the condensation of phosphonium ylides with aldehydes to generate alkenes. Non-stabilized ylides tend to produce Z-alkenes, while stabilized variants favor E-geometry, enabling stereoselective extension of the in compounds like . For instance, iterative applications have constructed the polyene backbone in β-carotene precursors with E-selectivity exceeding 90% under salt-free conditions. This method's tolerance makes it suitable for late-stage modifications, though purification of isomers can be required. Palladium-catalyzed Heck coupling provides an efficient route for vinylation of aryl or vinyl halides, extending polyene conjugation through migratory insertion and β-hydride elimination. This reaction typically yields E-alkenes due to the trans of the palladium intermediate, with ligands like phosphines enhancing selectivity. In polyene synthesis, it has been employed to couple vinyl iodides with acrylates, achieving up to 91:9 E/Z ratios at low catalyst loadings (1-5 mol%). The method's suits industrial intermediates, though it requires inert atmospheres to prevent side reactions. Olefin metathesis, catalyzed by ruthenium complexes such as Grubbs' second-generation catalysts, facilitates cross-metathesis of terminal alkenes to form internal di- or . This approach excels in assembling symmetric or unsymmetric by exchanging alkylidene groups, often with E-selectivity in non-strained systems. Yields for polyene extension reach 70-90% under mild conditions, making it valuable for fragments. Z-selective variants using stereogenic catalysts have emerged for precise geometry control. Stereocontrol in polyene synthesis is critical for , with E/Z selectivity achieved through reaction conditions, or design, and auxiliaries. In Horner-Wadsworth-Emmons (HWE) variants of the , chiral auxiliaries on phosphonates enable stereodivergent access to E- or Z-enones by modulating the geometry, attaining diastereoselectivities >95:5 with a single auxiliary. Chiral auxiliaries like oxazolidinones in aldol precursors further aid iterative E-selective olefination. These strategies minimize mixtures, often confirmed by NMR. For scalability, industrial production of polyenes favors microbial over purely chemical routes, leveraging engineered yeasts or for sustainable yields. Strains like Blakeslea trispora produce β-carotene at high titers, such as up to 4 g/L, through optimized fermentation, bypassing multi-step chemical syntheses while ensuring all-E configurations. This biotechnological method supports commercial demands, with processes achieving >90% purity post-extraction.

Key Examples and Mechanisms

One prominent example of polyene synthesis is the total synthesis of β-carotene, a tetraterpene carotenoid featuring a conjugated 11-double bond system. The industrial process developed by BASF employs a symmetric Wittig approach, involving the condensation of a C10 dialdehyde with two equivalents of a C15 Wittig ylide derived from β-ionone. The mechanism proceeds via nucleophilic attack of the ylide carbanion on the aldehyde carbonyl, forming a betaine intermediate that cyclizes to an oxaphosphetane, followed by syn-elimination to yield the trans-alkene and triphenylphosphine oxide byproduct, ensuring high E-selectivity in the polyene chain extension. This double condensation efficiently assembles the central polyene backbone, with subsequent deprotection yielding all-trans-β-carotene in high purity. The synthesis of all-trans-, a key of the polyene () that interconverts with the 11-cis form critical in visual , exemplifies chain extension from cyclic precursors. Starting from β-ionone, the process involves Grignard addition of vinylmagnesium bromide to introduce the initial side-chain unsaturation, forming a tertiary alcohol intermediate. This is followed by acid-catalyzed and elimination to establish the conjugated , with further Wittig olefination steps extending the polyene to the full C20 skeleton and introducing the terminal via oxidation. The Grignard step mechanism relies on magnesium coordination facilitating to the , followed by protonolysis, while eliminations proceed via E1cb pathways under acidic conditions to control double-bond geometry. Polyene such as , featuring a 7-membered heptaene system within a macrocyclic , are accessed through biosynthetic engineering and semi-synthetic modifications due to their complex architecture. Biosynthetic routes in nodosus involve polyketide synthase (PKS) assembly of the carbon skeleton from malonyl and methylmalonyl extenders, followed by P450-mediated oxidative tailoring to install the polyene and hydroxyl groups. Engineering efforts, such as targeted gene disruptions in amphN and amphDI clusters, enable production of simplified analogs like 30-ketoamphotericin, which retain the polyene motif while altering or mycosamine attachment via semi-synthetic . These approaches highlight the of genetic manipulation for core scaffold generation and chemical modification for polyene integrity. In polyene constructions, stepwise π-bond formation often occurs through cascade cyclizations, mimicking biosynthesis but adapted for synthetic control. For instance, in carotenoid-like systems, electrophilic activation of a polyene precursor by Lewis acids initiates sequential 6-endo cyclizations, where each new π-bond forms via capture by an internal , propagating the cascade with anti-Markovnikov selectivity. The mechanism involves chair-like transitions for stereocontrol, with quenching by nucleophiles to terminate the sequence, as seen in platinum-catalyzed polyene cycloisomerizations yielding fused rings with defined polyene conjugation. A key challenge in multi-step polyene syntheses is avoiding over-oxidation, which can cleave conjugated double bonds via or radical pathways, leading to chain fragmentation. Strategies include inert atmospheres, antioxidant additives like during workups, and sequential mild oxidants (e.g., MnO2 over KMnO4) to functionalize without degrading the , particularly in sequences where extended conjugation amplifies sensitivity.

Natural Occurrence and Biological Roles

Occurrence in Nature

Polyenes, characterized by their conjugated chains of double bonds, are ubiquitous in the natural world, with diverse chemical structures ranging from linear hydrocarbons to cyclic and oxygenated derivatives. They are primarily encountered as in photosynthetic organisms and retinoids in animals, as well as polyenes in certain , reflecting a broad chemical diversity adapted to various environmental niches. In plants and algae, represent the most abundant class of polyenes, synthesized by virtually all higher plants and many algal species to impart coloration and support . Notable examples include , a red linear polyene found in tomatoes and other fruits like watermelons, and , a ketocarotenoid present in high concentrations in the Haematococcus pluvialis. More than 1,100 unique have been identified, highlighting the structural diversity from carotenes to xanthophylls. In animals, polyenes occur mainly as retinoids, which are derived from dietary and feature a β-ionone ring conjugated to a polyene chain. A key example is , an 11-cis polyene bound to in , the visual pigment found in the rod cells of retinas. These compounds are present in tissues such as the liver and eyes across mammals, birds, and fish, obtained through the from and algal sources. Microbial sources contribute polyene , particularly antifungal compounds produced by actinobacteria. For instance, the bacterium noursei biosynthesizes nystatin, a heptaene macrolide with a conjugated polyene segment, as part of its . Some fungi also produce , such as β-carotene in species like Blakeslea trispora, adding to the microbial chemical diversity of polyenes. Geologically, polyene derivatives persist as biomarkers in ancient sediments, where diagenetic alteration of yields aromatized hydrocarbons like isorenieratane, indicative of past anoxygenic photosynthetic communities. These fossilized polyenes have been detected in marine shelf sediments and black shales dating back millions of years, providing evidence of microbial in prehistoric environments.

Biological Functions

Polyenes, particularly , serve essential roles in within plants, , and . In photosynthetic organisms, carotenoids function as accessory antenna pigments that absorb light in wavelength regions not captured by , thereby extending the range of usable solar energy and transferring excitation energy to the reaction centers via . Additionally, carotenoids act as photoprotectors by quenching excess energy through mechanisms, preventing the formation of harmful (ROS) that could damage photosynthetic machinery under high-light conditions. In animal vision, the polyene 11-cis-retinal plays a central role as the in proteins, enabling light detection and . Upon absorbing a , 11-cis-retinal undergoes to all-trans-retinal within the binding pocket of , triggering a conformational change in the opsin that activates downstream G-protein signaling pathways to initiate the visual response. This isomerization process, occurring in rod and cells of the , converts light energy into electrical signals for neural processing. Certain polyenes exhibit antifungal activity in biological systems, exemplified by amphotericin B produced by soil bacteria such as Streptomyces nodosus. This macrolide polyene binds specifically to ergosterol in fungal cell membranes, disrupting lipid packing and leading to the formation of transmembrane pores composed of 7-8 amphotericin B molecules complexed with ergosterol, which cause ion leakage and cell lysis. This mechanism provides a natural defense against fungal pathogens in microbial ecosystems. From an evolutionary perspective, polyenes like carotenoids likely emerged early in life's history to provide UV protection in primitive organisms. In ancient microbial mats and shallow-water environments exposed to intense ultraviolet radiation, carotenoids absorbed UV light and dissipated energy as heat, shielding DNA and proteins from photodamage and enabling survival in pre-oxygenated atmospheres. This photoprotective function, conserved across bacteria, archaea, and eukaryotes, underscores polyenes' role in facilitating the transition to aerobic life and diversification of early ecosystems.

Applications

Pharmaceutical Uses

Polyenes represent a class of agents that target fungal cell membranes, with (AmB) serving as the prototypical example for systemic infections. AmB is a heptaene polyene characterized by a of seven double bonds within its macrocyclic ring, which enables its interaction with s in lipid bilayers. This compound binds preferentially to , the primary in fungal membranes, over in human cells, forming barrel-shaped ion channels that disrupt membrane integrity. The resulting pores allow monovalent ions, particularly (K+), to leak out, leading to osmotic imbalance, loss of cellular , and eventual fungal . In clinical practice, AmB is indicated for treating severe systemic mycoses, including invasive , , , and , often in immunocompromised patients such as those with or undergoing . However, its use is limited by significant nephrotoxicity, which manifests as in approximately 46% of patients, along with and . Other polyene antifungals include nystatin, a tetraene polyene used topically or orally for superficial Candida infections such as oral thrush, diaper rash, and , due to its poor systemic absorption. Nystatin operates via a similar membrane-disrupting mechanism, binding to form pores and cause ion leakage. , another polyene , is employed ophthalmically for fungal and as a in products like cheese to inhibit mold growth, leveraging its ergosterol-binding pore-forming action. Recent advancements post-2020 have focused on mitigating AmB's toxicity through liposomal formulations, such as AmBisome, which encapsulate the drug in vesicles to reduce renal exposure while maintaining efficacy. These formulations have demonstrated lower rates of —around 10-20% compared to 50% with conventional AmB—and improved patient outcomes in trials for invasive fungal diseases, including single-dose regimens for cryptococcal . Generic liposomal versions approved by the FDA in 2021 have enhanced global accessibility, particularly in low-resource settings. As of 2025, ongoing has introduced polyene-based derivatives with modified structures to enhance potency and reduce , alongside polymer-mediated delivery systems like nanocarriers and prodrugs that improve targeted release and in fungal infections.

Materials and Optoelectronics

Polyenes and their derivatives, particularly conjugated polymers such as poly(p-phenylene vinylene) (PPV), serve as key emissive materials in organic light-emitting diodes (OLEDs) due to their tunable photoluminescence properties. In PPV-based devices, the extended π-conjugation enables efficient electron-hole recombination, producing light emission in the visible spectrum. For instance, ether-substituted PPV derivatives enhance solubility and device performance, achieving external quantum efficiencies suitable for display applications. To target blue light emission, structural modifications like incorporating fluorene or pyridine units into the polyene backbone shift the emission wavelength while maintaining high luminescence efficiency, as demonstrated in solution-processed OLEDs with peak emissions around 450 nm. In photovoltaic applications, polyene-based conjugated polymers act as electron donors in bulk heterojunction (BHJ) solar cells, where they form interpenetrating networks with acceptors like PCBM to facilitate dissociation and charge transport. The conjugation length of these polyenes directly influences the optical bandgap, with longer chains extending absorption into the near-infrared and improving power conversion efficiencies (PCEs); for example, MEH-PPV (a PPV derivative) in BHJ configurations has yielded PCEs exceeding 3%, highlighting the role of optimized conjugation in enhancing short-circuit currents. This dependence on conjugation length allows fine-tuning of energy levels to match acceptor offsets, minimizing recombination losses and boosting overall device performance in polymer- blends. Conjugated polyenes exhibit exceptional nonlinear optical (NLO) properties, stemming from their high second-order hyperpolarizability (β), which arises from the delocalized π-electrons along the alternating double bonds. This enables efficient (frequency doubling) in polyene chromophores, where donor-acceptor substitutions amplify β values by up to several orders of magnitude compared to non-conjugated analogs. Computational studies on push-pull polyenes with 8-10 double bonds have predicted β enhancements suitable for NLO devices, such as optical switches and lasers. Experimental validations in amino- and nitro-substituted polyenes confirm their utility for frequency doubling at visible wavelengths, with hyperpolarizabilities scaling favorably with chain length. As polymeric materials, conjugated polyenes contribute to through their inherent mechanical pliability and solution processability, enabling the fabrication of bendable devices like transistors and sensors. PPV and related polyene polymers form thin films on flexible substrates such as PET, retaining electrical conductivity under strain due to the robust π-backbone. For example, ladder-type polyene structures enhance thermal stability and charge mobility in stretchable organic circuits, supporting applications in . Recent advances in the have integrated polyene-like conjugated chains as organic spacers in two-dimensional (2D) perovskites, enhancing charge transport in tandem solar cells. These conjugated spacers, such as phenylpropylammonium derivatives, reduce interlayer barriers and boost carrier mobilities compared to insulating spacers, leading to wide-bandgap top cells with PCEs over 20% in single-junction configurations. When stacked with bottom cells, polyene-based 2D perovskite tandems have achieved overall efficiencies exceeding 25%, approaching the practical limits for hybrid while improving stability against moisture. In 2025, models have been applied to predict and optimize electronic properties of π-conjugated polyene polymers, accelerating the design of high-performance optoelectronic devices with improved stability and efficiency.

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