Ethinylestradiol/drospirenone

Ethinylestradiol/drospirenone
	Ethinylestradiol
	Drospirenone
Combination of
Ethinylestradiol	Estrogen
Drospirenone	Progestogen; Progestin; Antimineralocorticoid; Antiandrogen
Clinical data
Trade names	With 30 μg ethinylestradiol: Yasmin, others; With 20 μg ethinylestradiol: Yaz, Yasminelle, others
Other names	EE/DRSP; drospirenone/estradiol; drospirenone/ethinyl estradiol
AHFS/Drugs.com	Professional Drug Facts
MedlinePlus	a601050
License data	US DailyMed: Drospirenone and estradiol;
Pregnancy; category	AU: B3; ;
Routes of; administration	By mouth
ATC code	G03FA17 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); US: ℞-only;
Identifiers
CAS Number	164017-31-6;
KEGG	D09741;

Ethinylestradiol/drospirenone (EE/DRSP), sold under the brand name Yasmin among others, is a combination of ethinylestradiol (EE), an estrogen, and drospirenone (DRSP), a progestin, antimineralocorticoid, and antiandrogen, which is used as a birth control pill to prevent pregnancy in women.^[6]^[7]^[4]^[5]^[8] It is also indicated for the treatment of moderate acne, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and dysmenorrhea (painful menstruation) in women.^[7] The medication is taken by mouth and contains 30 μg EE and 3 mg DRSP per tablet (brand names Yasmin, others) or 20 μg EE and 3 mg DRSP per tablet (brand names Yaz, Yasminelle, Nikki, others).^[4]^[5] A formulation with levomefolic acid (vitamin B₉) has also been marketed (brand names Beyaz, Safyral, others), with similar indications.^[9]^[10] EE/DRSP is marketed widely throughout the world.^[11]

In 2023, it was the 154th most commonly prescribed medication in the United States, with more than 3 million prescriptions.^[12]^[13]

References

^ "Drospirenone / estradiol (Angeliq) Use During Pregnancy". Drugs.com. 6 September 2018. Retrieved 18 March 2020.
^ healthdirect.gov.au. "Yasmin".
^ healthdirect.gov.au. "Yaz".
^ ^a ^b ^c "Yasmin- drospirenone and ethinyl estradiol kit". DailyMed. 19 May 2023. Retrieved 26 October 2024.
^ ^a ^b ^c "Yaz- drospirenone and ethinyl estradiol kit". DailyMed. 19 May 2023. Retrieved 26 October 2024.
^ "Ethinylestradiol/Drospirenone". AdisInsight. Springer Nature Switzerland AG.
^ ^a ^b "Drospirenone/Ethinylestradiol low-dose - Bayer HealthCare Pharmaceuticals". AdisInsight. Springer Nature Switzerland AG.
^ Keam SJ, Wagstaff AJ (2003). "Ethinylestradiol/drospirenone: a review of its use as an oral contraceptive". Treatments in Endocrinology. 2 (1): 49–70. doi:10.2165/00024677-200302010-00005. PMID 15871554. S2CID 209144694.
^ "Ethinylestradiol/Drospirenone/Folic acid". AdisInsight. Springer Nature Switzerland AG.
^ "Beyaz- drospirenone/ethinyl estradiol/levomefolate calcium and levomefolate calcium kit". DailyMed. 19 May 2023. Retrieved 26 October 2024.
^ "Drospirenone Uses, Side Effects & Warnings". Drugs.com.
^ "Top 300 of 2023". ClinCalc. Archived from the original on 12 August 2025. Retrieved 12 August 2025.
^ "Drospirenone; Ethinyl Estradiol Drug Usage Statistics, United States, 2013 - 2023". ClinCalc. Retrieved 19 August 2025.