Pythons are found in sub-Saharan Africa, Nepal, India, Sri Lanka, Bangladesh, Southeast Asia, southeastern Pakistan, southern China, the Philippines and Australia.^[1]

Two known populations of invasive pythons exist in the Western Hemisphere. In the United States, an introduced population of Burmese pythons (Python bivittatus) has existed as an invasive species in Everglades National Park since the late 1990s. As of January 2023, estimates place the Floridian Burmese python population at around half a million. Local bounties are awarded and scientists study dead Burmese pythons to better understand breeding cycles and trends associated with rapid population explosion. The pythons readily prey on native North American fauna in Florida, including (but not limited to) American alligators, birds, bobcats, American bullfrogs, opossums, raccoons, river otters, white-tailed deer, and occasionally domestic pets and livestock. They are also known to prey on other invasive and introduced animals to Florida, such as the green iguana and nutria (coypu), though not at a rate as to lower their numbers rapidly or effectively.^[5]

In Puerto Rico, a population of reticulated pythons (Malayopython reticulatus) are known to be currently established, with a remarkably high rate of albinism, suggesting establishment from domesticated pet stock. Records of reticulated pythons date back to as early as 2009, and the population was recognized as established by 2017.^[6]

This section needs expansion. You can help by adding to it. (November 2022)

Many species have been hunted aggressively, which has greatly reduced the population of some, such as the Indian python (Python molurus) and the ball python (Python regius).^[7][8]

This section needs expansion. You can help by adding to it. (November 2022)

Most members of this family are ambush predators, in that they typically remain motionless in a camouflaged position, and then strike suddenly at passing prey. Attacks on humans, although known to occur, are extremely rare.^[9][10]

Pythons use their sharp, backward-curving teeth, four rows in the upper jaw, two in the lower, to grasp prey which is then killed by constriction; after an animal has been grasped to restrain it, the python quickly wraps a number of coils around it.^[11][12] Death occurs primarily by cardiac arrest.^[11][12] Even the larger species, such as the reticulated python (Malayopython reticulatus), do not crush their prey to death.^[13]

Larger specimens usually eat animals about the size of a domestic cat, but larger food items are known; some large Asian species have been known to take down adult deer, and the Central African rock python (Python sebae) has been known to eat antelope. The reticulated python is the only python species known to sometimes eat humans in its natural habitat in Sulawesi, Indonesia.^[14] All prey is swallowed whole, and may take several days or even weeks to fully digest.

Pythons are oviparous. This sets them apart from the family Boidae (boas), most of which bear live young (ovoviviparous). After they lay their eggs, females typically incubate them until they hatch. This is achieved by causing the muscles to "shiver", which raises the temperature of the body to a certain degree, and thus that of the eggs. Keeping the eggs at a constant temperature is essential for healthy embryo development. During the incubation period, females do not eat and leave only to bask to raise their body temperature.

Most species in this family are available in the exotic pet trade. However, caution must be exercised with the larger species, as they can be dangerous; rare cases of large specimens killing their owners have been documented.^[15][16]

Obsolete classification schemes—such as that of Boulenger (1890)—place pythons in Pythoninae, a subfamily of the boa family, Boidae.^[1] However, despite a superficial resemblance to boas, pythons are more closely related to the sunbeam snakes (Xenopeltis) and the Mexican burrowing python (Loxocemus).^[17][18]

Trade in python skins is a lucrative business with the export market from Southeast Asia estimated at US$1 billion as of 2012.^[20] Much of the trade is illegal, and python farming is very expensive.^[21] Pythons are poached for their meat, mostly consumed locally as bushmeat and their skin, which is sent to Europe and North America for manufacture of accessories like bags, belts and shoes.^[22]

In Cameroon bushmeat markets, the Central African rock python (Python sebae) is sold for meat.^[22] Hunting, killing and selling pythons is illegal in Cameroon under national wildlife law, but there is little to no enforcement.^[22]

Pythons are not venomous, but like other reptiles, they can be vectors for infections that affect humans, such as salmonella. Such diseases may be transmitted to humans through excreted waste, open wounds, and contaminated water.^[23][24][25]

Pythons are also integrated into some aspects of African health and belief use, often with the added risk of contacting zoonotic diseases. Python bodies and blood are used for African traditional medicines and other belief uses as well, one in-depth study of all animals used by the Yorubas of Nigeria for traditional medicine found that the African Python is used to cure rheumatism, snake poison, appeasing witches, and accident prevention.^{[citation needed]}

Python habitats, diets, and invasion into new areas also impact human health and prosperity. A University of Florida Institute of Food and Agriculture Sciences study found that the Burmese python, as an invasive species, enters new habitats and eats an increasing number of mammals, leaving limited species for mosquitoes to bite, forcing them to bite disease-carrying hispid cotton rats and then infect humans with the Everglades virus, a dangerous infection that is carried by very few animals.^[26] While direct human-python interactions can be potentially dangerous, the risk of zoonotic diseases is always a concern, whether considering medical and belief use in Nigeria or when addressing invasive species impacts in Florida. In 2022, a woman who lived near a lake area in south-eastern New South Wales state, Australia, was found to be infested with the Ophidascaris robertsi roundworm which is common in carpet pythons - non-venomous snakes found across much of Australia.^[27]

Python skin has traditionally been used as the attire of choice for medicine men and healers.^[28] Typically, South African Zulu traditional healers will use python skin in ceremonial regalia.^[28] Pythons are viewed by the Zulu tradition to be a sign of power. Healers are seen as all-powerful since they have a wealth of knowledge, as well as accessibility to the ancestors.^[28]

Typically, species are attributed to healing various ailments based on their likeliness to a specific bodily attribute. For example, in many cultures, the python is seen as a strong and powerful creature. As a result, pythons are often prescribed as a method of increasing strength.^[28] It is very common for the body fat of pythons to be used to treat a large variation of issues such as joint pain, rheumatic pain, toothache and eye sight.^{[citation needed]} Additionally, python fat has been used to treat those suffering from mental illnesses like psychosis.^[29] Their calm nature is thought to be of use to treat combative patients. The fat of the python is rubbed onto the body part that is in pain. To improve mental illnesses, it is often rubbed on the temple.^{[citation needed]} The existence of evidence for genuine anti inflammatory and anti-microbial properties of the refined 'snake oil' is ironic with respect to the expression "snake oil salesman".^[30]

The Sukuma tribe of Tanzania have been known to use python feces in order to treat back pain. The feces are frequently mixed with a little water, placed on the back, and left for two to three days.^[31]

In Nigeria, the gallbladder and liver of a python are used to treat poison or bites from other snakes.^{[citation needed]} The python head has been used to "appease witches". Many traditional African cultures believe that they can be cursed by witches. In order to reverse spells and bad luck, traditional doctors will prescribe python heads.^{[citation needed]}

In northwestern Ghana, people see pythons as a savior and have taboos to prevent the snake from being harmed or eaten. Their folklore states that this is because a python once helped them flee from their enemies by transforming into a log to allow them to cross a river.^[32]

In Botswana, San ritual practices surrounding pythons date back 70,000 years. In San mythology the python is a sacred creature that is highly respected.^[33] They believe that mankind was made by a python that moved in between hills to create stream beds.

In Benin, Vodun practitioners believe that pythons symbolize strength and the spirit of Dagbe ["to do good" in Yoruba]. Annually, people sacrifice animals and proclaim their sins to pythons that are kept inside temples.^[34]

• List of pythonid species and subspecies
• Python