Pyxis is a small and faint constellation in the southern sky. Abbreviated from Pyxis Nautica, its name is Latin for a mariner's compass (contrasting with Circinus, which represents a draftsman's compasses). Pyxis was introduced by Nicolas-Louis de Lacaille in the 18th century, and is counted among the 88 modern constellations.

The plane of the Milky Way passes through Pyxis. A faint constellation, its three brightest stars—Alpha, Beta and Gamma Pyxidis—are in a rough line. At magnitude 3.68, Alpha is the constellation's brightest star. It is a blue-white star approximately 880 light-years (270 parsecs) distant and around 22,000 times as luminous as the Sun.

Pyxis is located close to the stars that formed the old constellation Argo Navis, the ship of Jason and the Argonauts. Parts of Argo Navis were the Carina (the keel or hull), the Puppis (the stern), and the Vela (the sails). These eventually became their own constellations. In the 19th century, John Herschel suggested renaming Pyxis to Malus (meaning the mast) but the suggestion was not followed.

T Pyxidis, located about 4 degrees northeast of Alpha Pyxidis, is a recurrent nova that has flared up to magnitude 7 every few decades. Also, three star systems in Pyxis have confirmed exoplanets. The Pyxis globular cluster is situated about 130,000 light-years away in the galactic halo. This region was not thought to contain globular clusters. The possibility has been raised that this object might have escaped from the Large Magellanic Cloud.

In ancient Chinese astronomy, Alpha, Beta, and Gamma Pyxidis formed part of Tianmiao, a celestial temple honouring the ancestors of the emperor, along with stars from neighbouring Antlia.

The French astronomer Nicolas-Louis de Lacaille first described the constellation in French as la Boussole (the Marine Compass) in 1752, after he had observed and catalogued almost 10,000 southern stars during a two-year stay at the Cape of Good Hope. He devised fourteen new constellations in uncharted regions of the Southern Celestial Hemisphere not visible from Europe. All but one honoured instruments that symbolised the Age of Enlightenment. Lacaille Latinised the name to Pixis [sic] Nautica on his 1763 chart. The Ancient Greeks identified the four main stars of Pyxis as the mast of the mythological Jason's ship, Argo Navis.

German astronomer Johann Bode defined the constellation Lochium Funis, the Log and Line—a nautical device once used for measuring speed and distance travelled at sea—around Pyxis in his 1801 star atlas, but the depiction did not survive. In 1844 John Herschel attempted to resurrect the classical configuration of Argo Navis by renaming it Malus the Mast, a suggestion followed by Francis Baily, but Benjamin Gould restored Lacaille's nomenclature. For instance, Alpha Pyxidis is referenced as α Mali in an old catalog of the United States Naval Observatory (star 3766, page 97).

Covering 220.8 square degrees and hence 0.535% of the sky, Pyxis ranks 65th of the 88 modern constellations by area. Its position in the Southern Celestial Hemisphere means that the whole constellation is visible to observers south of 52°N. It is most visible in the evening sky in February and March. A small constellation, it is bordered by Hydra to the north, Puppis to the west, Vela to the south, and Antlia to the east. The three-letter abbreviation for the constellation, as adopted by the International Astronomical Union in 1922, is "Pyx". The official constellation boundaries, as set by Belgian astronomer Eugène Delporte in 1930, are defined by a polygon of eight sides (illustrated in infobox). In the equatorial coordinate system, the right ascension coordinates of these borders lie between 8^h 27.7^m and 9^h 27.6^m , while the declination coordinates are between −17.41° and −37.29°.