Elizabeth "Betty" Brant-Leeds is a fictional character appearing in American comic books published by Marvel Comics, usually in stories featuring the superhero Spider-Man. She is the personal secretary of J. Jonah Jameson at the Daily Bugle, and served as both a supporting character and love interest for Peter Parker, eventually marrying Ned Leeds/Hobgoblin. She later became a reporter for the Daily Bugle and the girlfriend of Flash Thompson/Agent Venom.

Since her inception, the character has been featured in various media adaptations, such as feature films, television series and video games. In film, she was portrayed by Elizabeth Banks in Sam Raimi's Spider-Man trilogy, and by Angourie Rice as a teenaged version in the Marvel Cinematic Universe (MCU) films Spider-Man: Homecoming (2017), Spider-Man: Far From Home (2019), and Spider-Man: No Way Home (2021) and the web series The Daily Bugle (2021–2022), with Antonina Lentini voicing another version in Spider-Man: Across the Spider-Verse (2023); the What If...? Spider-Girl incarnation of Betty Brant also cameos in Spider-Man: Shattered Dimensions, Spider-Man Unlimited, and Across the Spider-Verse.

Created by writer Stan Lee and artist Steve Ditko, she first appeared in The Amazing Spider-Man #4 (September 1963).

Betty Brant was born in Philadelphia. Her mother had originally been the "Girl Friday" of Daily Bugle editor J. Jonah Jameson, and Betty dropped out of high school to become Jameson's secretary at the Daily Bugle after her mother suffered serious injury. As Peter Parker's first love, she met him when he became a freelance photographer for the Bugle. After they had been attacked by the Vulture, Peter had already noticed his attraction to Betty, and was impressed when she stood up to Jameson over publishing slandering articles against Spider-Man. They began dating shortly afterwards, when Betty was impressed by Parker's kindness when taking care of his ill Aunt May.

Her secretarial job at the Bugle was taken to help her brother Bennett Brant pay back his gambling debts, which he had acquired trying to pay for their mother's medical bills. Bennett had become friendly with Betty's then boyfriend Gordon Savinski. Gordon was into many illegal activities and Bennett eventually took on a gambling debt that he could not pay back to a gangster named Blackie Gaxton. When Gaxton's thugs came looking for Bennett at the family home, Betty's mother was knocked into a coffee table, resulting in permanent brain damage.

With the help of Doctor Octopus, Gaxton kidnapped both Bennett and Betty as insurance against anyone preventing him leaving the country. Bennett was double crossed when Glaxton refused to free him of his debts and was fatally shot during a melee between Glaxton's gang, Doctor Octopus and Spider-Man. At first, Betty blamed Spider-Man for the death of her brother and told Spider-Man that she never wanted to see him again, although afterwards she realized she had been wrong and that he had only been trying to help. The blossoming romance between Betty and Peter was cut short, when Betty feared that Peter cared more for his classmate Liz Allan. This misunderstanding led to their relationship finally coming to an end.

Soon after Peter and Betty's break up, she started dating fellow Daily Bugle employee reporter Ned Leeds. Even though he soon left for Europe, they remained in contact, writing each other letters regularly. Upon his return, they began dating again, and Leeds eventually proposed to Betty. There were signs that Betty still loved Peter, and Peter did his best to alienate her for her own good. She eventually accepted Leeds' marriage proposal.

After their engagement, J. Jonah Jameson threw an engagement party at his penthouse apartment and their wedding soon followed. Their wedding day was not all smooth sailing as a costumed criminal named Mirage decided to rob all the guests at the top weddings on that day. Spider-Man intervened and Mirage was easily captured. Betty and Ned were married with Mary Jane Watson serving as Betty's maid of honor.