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Hypericaceae
Temporal range: Eocene–recent[1] Possible Late Cretaceous record
Hypericum tetrapterum
Scientific classification Edit this classification
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Rosids
Order: Malpighiales
Family: Hypericaceae
Juss.[2]
Genera[3]

Hypericaceae is a plant family in the order Malpighiales, comprising six to nine genera and up to 700 species, and commonly known as the St. John's wort family. Members are found throughout the world apart from extremely cold or dry habitats. Hypericum and Triadenum occur in temperate regions but other genera are mostly tropical.

Characteristics

[edit]

Members of this family are annual or perennial herbs, subshrubs or shrubs. The leaves are simple and entire, in opposite pairs; they are sometimes dotted with black or translucent glandular spots. The inflorescence consists of a branched, flat-topped cluster, each flower being radially symmetrical, with a superior ovary. Flowers have the following components: sepals, four or five, which tend to persist; petals four or five, usually yellow, sometimes dotted with black specks; stamens many, on long filaments; styles, three to five, often fused at the base. The fruit has a dehiscent capsule which splits open when ripe to release the fine black seed.[4]

Taxonomy

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At one time, this family was accepted as a subfamily of the family Clusiaceae. Now it has been elevated to full family status. In Phytotaxa, six genera and around 590 species are listed,[5] and Plants of the World Online recognises six genera and around 700 species.[3] Members of the family are found worldwide except in excessively cold or dry areas. Most of the genera are mainly tropical, but Hypericum and Triadenum are found in temperate regions.[6] Molecular data supports the monophyly of Hypericaceae.[7]

When accepted as a complete family, the cladogram of Hypericaceae would appear as such:[8]

Hypericaceae

Pharmacology

[edit]
Common St. John's wort

Many members of this family contain the naphthodianthrone derivatives hypericin and pseudohypericin; these are contained in glandular tissues that appear as black, orange or translucent spots or lines on petals, leaves and other parts of the plant. These compounds are photosensitive and can cause reactions in grazing animals, such as blistering of the muzzle, as well as in people who come into contact with the plants over prolonged periods.[6] The highest concentration of these substances occurs in common St. John's wort (Hypericum perforatum), which is used in herbalism and as a folk remedy.[9]

References

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[edit]
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Hypericaceae

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Hypericaceae is a family of flowering plants in the order Malpighiales, commonly known as the St. John's wort family, comprising approximately nine genera and more than 700 species of annual or perennial herbs, subshrubs, shrubs, and rarely trees.[1] These plants are characterized by opposite (sometimes alternate or whorled), simple, estipulate leaves that are often sessile to petiolate and feature pellucid (translucent) glands or canals as well as dark glands containing hypericin or pseudohypericin.[1] Flowers are bisexual and actinomorphic, typically with (3–)4–5 sepals, an equal number of orange, pink, yellow, or white petals that are gland-dotted, and numerous stamens arranged in two whorls or fascicles; the superior ovary develops into a septicidally dehiscent capsule or rarely a berry.[1][2] The family is nearly cosmopolitan in distribution, excluding very cold and arid regions, with the majority of species occurring in tropical and subtropical areas, while the genus Hypericum—the largest with around 500 species—predominates in temperate zones.[1][3] Notable genera include Hypericum, Triadenum, Vismia, and Cratoxylum, with Hypericum perforatum (common St. John's wort) being a widespread species valued for its medicinal properties, including use as an antidepressant, though it can cause photosensitization in livestock due to hypericin content.[1][4] Ecologically, members of Hypericaceae often inhabit sunny, open habitats such as meadows, roadsides, and forest edges, and the family was historically treated as a subfamily of Clusiaceae but is now recognized as distinct based on molecular and morphological evidence.[5][2]

Botanical description

Vegetative morphology

Members of the Hypericaceae family exhibit diverse growth habits, ranging from annual and perennial herbs to subshrubs, shrubs, and rarely trees, with some species reaching heights of up to 2 meters.[1][6] The family primarily consists of herbaceous perennials, though shrubby forms are common in certain lineages, such as sections of the genus Hypericum where a bushy, spreading habit predominates.[7] For instance, Hypericum prolificum forms a compact deciduous shrub up to 2 meters tall with multiple branching stems.[6] Stems in Hypericaceae are typically erect or decumbent, glabrous or pubescent with simple hairs, and often feature longitudinal ridges—commonly two, four, or six—that align with the opposite-decussate leaf arrangement.[1][7] These ridges can vary from subtle lines to more pronounced wing-like structures, and stems may be terete in some species. In Hypericum perforatum, stems are woody at the base, branched primarily in the upper half, and reach 30–100 cm in height, supporting a leafy, upright form.[8] Translucent or dark glandular dots frequently occur along the stem ridges, contributing to the family's characteristic secretory structures.[7] Leaves are simple, estipulate, and arranged oppositely (sometimes alternate or in whorls), usually sessile or with short petioles, and feature entire margins.[1][2] Shapes range from ovate to linear, with lengths typically 1–3 cm and widths 0.15–0.5 cm, often displaying pellucid (translucent) glandular dots or canals filled with essential oils, alongside black, reddish, or amber glands containing hypericin and related compounds.[1][7] In Hypericum perforatum, leaves are oblong to ovate, opposite, and sessile, measuring 1.5–3 cm long and 1.5–5 mm wide, with numerous translucent dots and marginal black glands visible under magnification.[8] These glandular features are diagnostic for identification and link to the family's phytochemistry without altering the vegetative form.[7]

Reproductive morphology

The flowers of Hypericaceae are bisexual and actinomorphic, with (3–)4–5 sepals that are persistent or deciduous, imbricate, and often bearing glands.[9] Petals number 3–5(–6), are distinct and imbricate or contorted, typically colored yellow, orange, or pink, and are frequently glanduliferous, featuring black marginal dots or glands in many species such as Hypericum perforatum.[9] In the genus Hypericum, petals are commonly golden-yellow and five in number, whereas in Triadenum, they are pink and also five-petaled but shorter-lived, opening late in the day.[10] The stamens are numerous and hypogynous, arranged in 3–5 fascicles or bundles, with filaments that are distinct or partially connate; anthers are two-locular and dehisce longitudinally.[11] In Triadenum, stamens are reduced to 9–12, organized in three fascicles of three each, contrasting with the more numerous (up to 100+) in Hypericum.[10] Styles number 2–5, are slender and distinct or basally connate, bearing capitate to clavate stigmas.[9] Inflorescences are terminal or axillary, forming cymes (often thyrsoid) or occasionally solitary flowers, with pedicels supporting the blooms.[12] The ovary is superior, 2–5-merous and 1–5-locular, with axile to parietal placentation and numerous anatropous ovules per placenta.[9] Fruits are typically capsular, dehiscing septicidally from the apex (rarely loculicidal), and occasionally baccate in some taxa; the capsules arise from the superior ovary and contain multiple seeds.[12] Seeds are small (0.37–1.91 mm long), cylindric-ellipsoid to prolonged cylindric, brown to dark brown in color, with a reticulate or foveolate surface ornamentation that appears finely pitted under microscopy, and they lack endosperm, featuring a straight or curved embryo with cotyledons comprising 25–40% of its length.[13][9] In species like Hypericum perforatum, seeds are darkly colored and numerous within each capsule locule, aiding in wind or animal dispersal.[14]

Taxonomy and phylogeny

Classification history

The family Hypericaceae was originally described by Antoine Laurent de Jussieu in 1789 as a distinct entity in his Genera Plantarum, based on the type genus Hypericum and its characteristic features.[4] In later 19th- and early 20th-century classifications, however, genera now assigned to Hypericaceae were frequently subsumed into the broader family Guttiferae (synonym for Clusiaceae), where they were treated as the subfamily Hypericoideae due to perceived similarities in secretory structures and overall habit.[3] By the mid-20th century, accumulating evidence from morphological studies prompted the recognition of Hypericaceae as a separate family, primarily distinguished from Clusiaceae by differences in floral organization—such as consistently bisexual flowers with free stamens and filaments in Hypericaceae versus often dioecious flowers with stamens connate into masses in Clusiaceae—and pollen characteristics, including the retention of distinct anthers in Hypericaceae.[1] This elevation to family rank was adopted in several influential systems, including those by Adolf Engler and subsequent revisions, reflecting a shift toward emphasizing these reproductive traits for delimitation.[3] Molecular phylogenetic analyses in the late 20th and early 21st centuries confirmed the monophyly of Hypericaceae and its placement within the order Malpighiales, separate from Clusiaceae, through studies utilizing chloroplast genes like rbcL and nuclear ribosomal ITS sequences. The Angiosperm Phylogeny Group (APG) III classification in 2009 and APG IV in 2016 solidified this status, integrating Hypericaceae into the clusioid clade of Malpighiales while affirming its distinct evolutionary lineage based on multi-gene phylogenies. Within Hypericaceae, significant taxonomic refinements have focused on the genus Hypericum, the family's largest component, with Norman K. B. Robson providing key sectional revisions through extensive monographic work from the 1970s onward; his 1977 provisional classification divided Hypericum into 36 sections based on integrated morphological, anatomical, and geographical data, later updated in 2001 to incorporate new species and adjust boundaries.[15] These contributions have underpinned much of the modern infrageneric understanding, though ongoing molecular studies continue to test sectional monophyly.[16]

Genera and species diversity

The Hypericaceae family consists of nine genera encompassing approximately 700 species distributed across temperate and tropical regions worldwide.[17] However, molecular studies suggest that some small genera (e.g., Triadenum, Thornea) may be nested within Hypericum, leading to proposals for merger and reducing the family to about six genera.[18][4] The genus Hypericum dominates the family's diversity, accounting for roughly 500 species organized into 36 sections based on morphological and phylogenetic criteria.[19] Hypericum perforatum L., the common St. John's wort, serves as the type species for the genus, exemplifying its widespread herbaceous habit. Other genera contribute smaller but significant portions to the family's species richness. Triadenum includes about 10 species of temperate herbaceous plants primarily in eastern North America and eastern Asia.[20] Cratoxylum comprises around 7–15 species of trees endemic to Southeast Asia.[21] Harungana is monotypic, represented solely by the African tree Harungana madagascariensis Lam. ex Poir. Vismia features approximately 25 neotropical shrub and tree species, while Psorospermum contains about 40–50 African species, mainly shrubs and small trees.[22] The remaining genera—Eliea, Lianthus, and Santomasia—are each monotypic, while Thornea comprises two species (Thornea macrantha (A. Gray) Breedlove & E.M.McClint. and T. matudae (Lundell) Breedlove & E.M.McClint.), with species restricted to specific regions such as Madagascar (Eliea articulata (Lam.) Cambess.) and Central America.[23] Diversity patterns in Hypericaceae are heavily skewed toward Hypericum, with major centers of species richness in Eurasia (over 230 species) and the Andes (over 130 species), reflecting adaptive radiations in temperate and montane habitats. Recent taxonomic updates continue to refine this inventory; for instance, Hypericum shunhuangshanense Y.Y Qian, Z.H. Chen & R.H. Luo was described in 2025 from China, highlighting ongoing discoveries in eastern Asian hotspots.[24] Phylogenetic studies confirm the family's monophyly, supporting the current generic circumscription while noting historical mergers of smaller genera into Hypericum.[25]

Distribution and ecology

Global distribution

The Hypericaceae family exhibits a cosmopolitan distribution, occurring across all continents except Antarctica, with a notable absence from extreme cold regions such as the Arctic and arid desert environments.[1][17] This broad range reflects the family's adaptability to temperate and tropical climates, though it avoids the most severe environmental extremes. The genus Hypericum, which dominates the family in terms of species diversity, shows a particular temperate focus, contributing significantly to the overall biogeographic patterns.[17] Areas of highest diversity include temperate Eurasia, particularly in Turkey where approximately 110 taxa of Hypericum are recorded, the Mediterranean Basin, and the Andean regions of South America.[26] In contrast, tropical genera such as Vismia are concentrated in Central and South America, with extensions into parts of Africa, underscoring the family's dual temperate-tropical affinity.[27] Several species have been introduced outside their native ranges, notably Hypericum perforatum, which arrived in North America by the late 18th century and in Australia and New Zealand during the 19th century, often for ornamental or medicinal purposes.[28] These introductions have facilitated the family's spread into new temperate zones. Endemism hotspots, such as Southeast Asia for the genus Cratoxylum, highlight regional concentrations of unique taxa within the family.[29]

Habitat preferences

Species in the Hypericaceae family predominantly occupy sunny, open habitats including meadows, roadsides, forest edges, and disturbed areas.[8] They exhibit tolerance for nutrient-poor, acidic soils, thriving in well-drained, coarse-textured conditions that range from sandy to loamy substrates.[30] Certain genera demonstrate remarkable adaptability to moisture variability; for instance, Triadenum species favor wetland environments such as bogs, marshes, fens, and pond margins, where they endure periodic waterlogging and peaty, saturated soils.[10] This versatility allows the family to persist in both dry upland sites and moist lowlands across their range. Ecologically, Hypericaceae contribute to ecosystem dynamics through multiple interactions. Their vibrant yellow flowers, rich in pollen, attract a diverse array of pollinators including bees, hoverflies, and butterflies, supporting insect-mediated reproduction and biodiversity in open habitats.[31] Root systems of species like Hypericum perforatum aid in soil stabilization, preventing erosion on slopes and in disturbed landscapes by binding loose substrates.[31] Additionally, Hypericum exhibits allelopathic properties, with extracts from leaves and stems inhibiting seed germination and growth of competing plants such as Lactuca sativa, potentially extending to root-mediated suppression in natural settings.[32] Many Hypericaceae species are adapted to disturbance regimes, enhancing their persistence in dynamic environments. For example, Hypericum cumulicola in fire-prone Florida rosemary scrub relies on periodic burns to promote germination and population growth, with smoke cues triggering seed dormancy release.[33] In Mediterranean shrublands, genera including Hypericum respond to fire with resprouting or seeding strategies, maintaining presence amid recurrent disturbances.[34] Invasive tendencies, particularly of H. perforatum, facilitate rapid colonization of disturbed grasslands and overgrazed areas, where they outcompete natives in temperate and subtropical zones.[28] The family's climatic distribution spans subtropical to temperate regions, with Hypericum dominant in cooler zones and other genera like Cratoxylum in tropical montane areas.[1] While avoiding extreme aridity or cold, some tropical species occupy shaded understory positions in humid forests, reflecting phylogenetic shifts toward diverse microhabitats.[35]

Phytochemistry

Characteristic compounds

The Hypericaceae family is distinguished by a suite of secondary metabolites, particularly naphthodianthrones, phloroglucinols, flavonoids, and xanthones, which contribute to its biochemical profile. These compounds are primarily synthesized and accumulated in specialized glandular structures, such as the punctate dark glands observed in many species.[36] Naphthodianthrones, exemplified by hypericin and pseudohypericin, are hallmark constituents of the genus Hypericum, where they impart the characteristic red pigmentation to the plant tissues and exhibit photosensitivity due to their ability to generate reactive oxygen species upon light exposure.[36][37] These compounds are biosynthesized through the polyketide pathway, involving type III polyketide synthases (PKSs) that condense acetyl-CoA with multiple units of malonyl-CoA to form anthraquinone precursors like emodin anthrone, with subsequent cyclization and oxidation steps leading to the final naphthodianthrone structures.[38] In Hypericum perforatum, for instance, a specific PKS enzyme (HpPKS2) demonstrates octaketide synthase activity, producing intermediates such as SEK4 and SEK4b, though additional enzymatic factors are required for complete hypericin formation in vivo.[38] Hypericin and pseudohypericin are predominantly concentrated in the dark glands of leaves, flowers, and fruits, highlighting their role in the family's chemical defense and pigmentation.[36] Phloroglucinols, including hyperforin and adhyperforin, represent another key class of acylphloroglucinols in Hypericaceae, mainly in Hypericum species, where they display antibiotic properties through disruption of microbial membranes.[37] These lipophilic compounds accumulate in the aerial parts, particularly in developing fruits and flowers, and their biosynthesis likely derives from polyketide-derived precursors similar to those of naphthodianthrones, though specific pathways remain less characterized. Recent studies using single-cell RNA sequencing have elucidated modules of the hyperforin biosynthetic pathway, involving polyketide formation in the cytosol and prenylation steps.[36][39] Flavonoids such as quercetin and kaempferol are ubiquitous phenolic compounds across Hypericaceae, often glycosylated and contributing to the yellow hues in floral tissues, while essential oils composed of monoterpenes and sesquiterpenes are secreted in translucent glands.[36][37] Phytochemical profiles vary notably among genera; for example, naphthodianthrones like hypericin predominate in Hypericum, whereas xanthones—oxygenated polycyclic aromatics with prenyl and hydroxyl substitutions—are more prominent in Cratoxylum, as seen in species like C. cochinchinense where they form complex mixtures distinct from the quinone-based hypericins.[40] This intergeneric diversity underscores the family's evolutionary adaptations in secondary metabolism. Recent biotechnological approaches, including CRISPR/Cas9 editing and elicitor treatments, have been employed to enhance production of these compounds in Hypericum species as of 2024.[40][41]

Human uses

Traditional and medicinal uses

Hypericaceae species, particularly Hypericum perforatum (St. John's wort), have been employed in traditional medicine since ancient times for treating wounds, depression, and anxiety. In ancient Greece, Hippocrates and other physicians documented its use as a remedy for various ailments, including as a diuretic, wound healer, and treatment for melancholy, with records extending to Roman and medieval European herbal traditions where it was applied topically for burns and internally for mood disorders. In African traditional medicine, species such as Psorospermum febrifugum have been widely used to treat malaria and related fevers, often prepared as decoctions or infusions from roots and bark to alleviate symptoms of the disease.[42][43][44][45] In modern pharmacology, the antidepressant effects of H. perforatum are primarily attributed to hyperforin, which inhibits the reuptake of serotonin, norepinephrine, and dopamine by elevating intracellular sodium levels, thereby enhancing monoamine neurotransmission in a manner distinct from selective serotonin reuptake inhibitors (SSRIs). Hypericin, another key compound, exhibits anti-inflammatory properties by reducing pro-inflammatory cytokine expression and antiviral activity through inactivation of enveloped viruses, such as herpes simplex virus, by altering viral proteins rather than nucleic acids. These mechanisms have been validated in preclinical studies, supporting the plant's historical applications.[46][47][48][49][50] Clinical evidence from meta-analyses indicates that H. perforatum extracts are effective for mild to moderate depression, with efficacy comparable to SSRIs in reducing Hamilton Depression Rating Scale scores, as shown in randomized trials involving over 5,000 participants. A 2023 meta-analysis of 14 randomized controlled trials indicated that St. John's wort (SJW) extracts reduce Hamilton Depression Rating Scale (HAMD) scores with fewer side effects compared to SSRIs. A 2017 meta-analysis of 27 trials confirmed efficacy comparable to SSRIs for mild to moderate depression, with earlier reviews showing superiority over placebo; benefits typically emerge within 4-6 weeks. As of 2025, recent reviews continue to support its use, with some indicating higher efficacy than prescription antidepressants in mild cases and studies on fresh plant tinctures showing tolerability and symptom reduction.[51][52][53][54][55][56] However, H. perforatum induces CYP3A4 enzyme activity, leading to significant drug interactions that reduce efficacy of substrates like oral contraceptives, anticoagulants (e.g., warfarin), and immunosuppressants (e.g., cyclosporine).[57] Safety concerns with H. perforatum include photosensitivity, manifesting as increased sunburn risk due to hypericin's photodynamic effects, particularly in fair-skinned individuals or at doses exceeding 900 mg/day. Contraindications encompass concurrent use with serotonergic drugs due to mania risk in bipolar disorder, and it is advised against in pregnancy or with photosensitizing medications. Overall, while generally well-tolerated for short-term use in mild depression, monitoring for interactions is essential.[58][59][60]

Horticultural and other uses

Species of Hypericum, the primary genus in the Hypericaceae family, are widely cultivated as ornamental perennials in gardens due to their attractive yellow flowers and colorful berries. These plants thrive in well-drained soils and full sun, adding vibrant summer blooms and autumn interest through persistent berries that range from red to black, enhancing landscape aesthetics. Popular cultivars such as Hypericum × hidcoteense 'Hidcote' are particularly valued for their compact form and suitability as low hedges or border plants, reaching about 1 meter in height with showy, fragrant flowers.[61][62][63] Beyond ornamentals, Hypericaceae species have practical applications, including natural dyeing where hypericin from Hypericum perforatum yields red pigments for textiles like wool and silk. Historically, this compound has been extracted to produce violet-red dyes, often using ethanol or alum mordants for colorfastness. Limited use as fodder occurs in some regions, though toxicity from hypericin restricts this; livestock such as cattle and sheep avoid mature plants when alternatives are available, but ingestion via hay can cause photosensitization. In ecological restoration, certain Hypericum species are employed for erosion control on slopes due to their robust root systems that stabilize soil, though invasive potential requires careful site selection.[64][65][66] Hypericum perforatum has become a noxious weed in North America, introduced from Europe and spreading aggressively in pastures and rangelands, where it reduces forage quality and poses toxicity risks to livestock. Biological control efforts began in the 1940s with the introduction of leaf beetles such as Chrysolina quadrigemina and C. hyperici, which feed on foliage and have significantly reduced populations in infested areas like California rangelands. Culturally, Hypericum holds significance in European folklore as a protective symbol against evil spirits, often hung over doors or burned in midsummer rituals to ward off malevolent forces, a tradition linked to its association with St. John the Baptist.[67][68][69][70]

References

  1. Hypericaceae - FNA - Flora of North America
  2. Hypericaceae - Jepson Herbarium
  3. Hypericaceae - an overview | ScienceDirect Topics
  4. Hypericaceae Juss. | Plants of the World Online | Kew Science
  5. Hypericaceae (st. john's-wort family) - Go Botany - Native Plant Trust
  6. Shrubby St. John's Wort Guide - New York Natural Heritage Program
  7. Morphological and Phytochemical Diversity among Hypericum ...
  8. Species: Hypericum perforatum - Forest Service
  9. Hypericaceae in Flora of North America @ efloras.org
  10. Triadenum virginicum (Virginia marsh-St. John's-wort) - Go Botany
  11. Taxonomy and Chemotaxonomy of the Genus Hypericum - PMC
  12. Hypericaceae Juss. - World Flora Online
  13. Seed morphology of Hypericum (Hypericaceae) in China and its ...
  14. [PDF] Common St. Johnswort (Hypericum perforatum) Plant Guide
  15. Details - Studies in the genus Hypericum L. (Guttiferae) 4(2). Section ...
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  17. Chloroplast Genome Diversity and Molecular Evolution in ... - MDPI
  18. A new species of Hypericum section Taeniocarpium (Hypericaceae ...
  19. Triadenum (Marsh St. John's-wort) - FSUS
  20. Cratoxylum Blume | Plants of the World Online | Kew Science
  21. Psorospermum febrifugum Spach (Hypericaceae): Ethnomedicine ...
  22. Molecular phylogenetics and morphological evolution of St. John's ...
  23. Hypericum shunhuangshanense (Hypericaceae), a new species ...
  24. Explosive radiation in high Andean Hypericum—rates of ... - Frontiers
  25. Hypericum celikaensis (Hypericaceae), a new species ... - BioOne
  26. In Vitro Antioxidant Activity and Qualitative Phytochemical Analysis ...
  27. Hypericum perforatum (St John's wort) | CABI Compendium
  28. Towards 3 Million: Hypericaceae - Botanics Stories
  29. FPS-261/FP261: Hypericum spp. St. John's Wort - University of Florida
  30. [PDF] Common St. Johnswort (Hypericum perforatum) Fact Sheet
  31. Germination and growth inhibitory effects of Hypericum myrianthum ...
  32. A Fire‐Explicit Population Viability Analysis of Hypericum cumulicola ...
  33. [PDF] Effects of aqueous smoke and nitrate treatments on germination of ...
  34. Oligocene niche shift, Miocene diversification – cold tolerance and ...
  35. Chemical Characterization and Antioxidant Activity of Nine ... - NIH
  36. Hypericaceae - an overview | ScienceDirect Topics
  37. Octaketide‐producing type III polyketide synthase from Hypericum ...
  38. Xanthones with Potential Anti-Inflammatory and Anti-HIV Effects from ...
  39. History and therapeutic properties of Hypericum Perforatum from ...
  40. Medicinal Herbs in Ancient Greece - The Greek Herbalist
  41. Psorospermum febrifugum - Useful Tropical Plants
  42. Evaluation of 13 selected medicinal plants from Burkina Faso for ...
  43. Hyperforin, a major antidepressant constituent of St. John's Wort ...
  44. Hyperforin: Uses, Interactions, Mechanism of Action | DrugBank Online
  45. Medical Attributes of St. John's Wort (Hypericum perforatum) - NCBI
  46. Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a ...
  47. Antiviral Activity Against Infectious Bronchitis Virus and Bioactive ...
  48. The efficacy and safety of St. John's wort extract in depression ...
  49. Meta-analysis The efficacy and safety of St. John's wort extract in ...
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  57. https://www.monrovia.com/be-inspired/berry-splendid-growing-floralberry-st-johns-wort.html
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  65. St. John's Wort: Ancient Herbal Protector - Christopher Hobbs
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