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CD70
CD70
CD70
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CD70 molecule
Identifiers
SymbolCD70
Alt. symbolsCD27LG, TNFSF7
NCBI gene970
HGNC11937
OMIM602840
RefSeqNM_001252
UniProtP32970
Other data
LocusChr. 19 p13
Search for
StructuresSwiss-model
DomainsInterPro

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. CD70 is also known as a ligand for CD27.[1]

Expression

[edit]

In physiological condition the expression of CD70 on immune cells is transient and tightly controlled. It is primarily expressed on highly activated T cells and B cells, as well as on NK cells and mature dendritic cells. CD70 expression on T and B cells is stimulated through triggering of T and B cell receptors and can be upregulated by cytokines such as IL-1α, IL-2, IL-12, GM-CSF and TNF-α, while IL-4 and IL-10 can decrease CD70 expression.[2] Expression of CD70 on mDCs and pDCs is induced with Toll-like receptor (TLR) triggering and CD40 ligation.[3] Also, CD70 can be induced on NK cells upon stimulation with IL-15.[4]

Functions

[edit]

CD70 acts as a costimulatory molecule and plays an important role in the regulation of the immune system activation, specifically by improving T-cell and B-cell activation, proliferation and survival, leading to a more efficient immune response.[5]

CD70 on activated antigen presenting cells (APC) including dendritic cells and B cells binds to CD27 on T lymphocytes and provides costimulatory signals. The interaction between CD27 and CD70 leads to the recruitment of intracellular adaptor proteins, such as TRAF2 and TRAF5, which then activate signaling pathways, including the NF-κB and JNK pathway.[6][7] CD27 signaling stimulates naïve CD4+ T lymphocytes to differentiate into Th1 cells by activation the transcription factor T-bet.[7]

In addition to its role in T-cell activation and proliferation, CD70 also plays a role in the regulation of B-cell activation and differentiation. Receptor engagement can also cause reverse signaling through CD70. CD70 reverse signaling activates the phosphatidylinositol-3 kinase (PI3K) and MAP kinase signaling pathways, leading to the activation of various transcription factors and the expression of genes involved in cell growth and survival.[8]

Clinical significance

[edit]

Cancer

[edit]

Some studies have shown that CD70 is overexpressed in several types of cancer, including Hodgkin's lymphoma and non-Hodgkin's lymphoma. CD70 is also found to be overexpressed in some types of solid tumors.[9][10][11] This overexpression of CD70 in cancer cells has been shown to promote cell proliferation and survival, and to inhibit apoptosis, leading to the development and progression of the cancer. It is therefore suggested that anti-CD70 antibodies might be a possible treatment for CD70 positive lymphomas as normal lymphocytes have low CD70 expression.[12]

Drug development

[edit]

Recent research has focused on the potential therapeutic use of CD70 in cancer treatment. One strategy being investigated is the use of antibodies that target CD70. ARGX-110 is a CD70-specific antibody that is currently under investigation for the treatment of hematological malignancies. It is being developed by the Belgian company arGEN-X. In December 2013 a first part of a phase 1b trial was completed. In January 2014 a safety and efficacy phase of the study started.[13]

Vorsetuzumab mafodotin is a CD70-targeted antibody-drug conjugate that started clinical trials for renal cell carcinoma.[14]

See also

[edit]

References

[edit]
[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

CD70

View on Grokipedia
from Grokipedia
CD70, also known as CD27 (CD27L) or ligand superfamily member 7 (TNFSF7), is a type II transmembrane and a member of the (TNF) superfamily that functions as the primary for the CD27 receptor (TNFRSF27). It has a molecular weight of approximately 50 kDa and forms homotrimers to mediate its signaling activity. CD70 plays a central role in adaptive immunity by providing costimulatory signals that enhance T-cell proliferation, differentiation into effector cells, and formation, while also regulating B-cell activation, natural killer (NK) cell function, and immunoglobulin synthesis. In physiological conditions, CD70 expression is tightly regulated and transiently induced on the surface of activated antigen-presenting cells, such as B lymphocytes, dendritic cells, and subsets of T cells, primarily during antigen-specific immune responses to prevent chronic activation and maintain immune homeostasis. The CD70-CD27 interaction delivers bidirectional signals: on T cells, it promotes survival and effector functions via and JNK pathways; on ligand-expressing cells, it can induce or proliferation depending on the cellular context. This pathway is essential for formation, production, and protection against viral infections, but its dysregulation can tip the balance toward tolerance or . Aberrant CD70 expression is a hallmark of various hematological and solid malignancies, including , , and , where it is constitutively upregulated on tumor cells and associated tumor-infiltrating regulatory T cells, fostering immune evasion, tumor proliferation, and . In cancer, CD70 acts as both an oncogenic driver—promoting lymphomagenesis through enhanced survival signals—and an by inducing T-cell exhaustion. Consequently, CD70 has emerged as a promising therapeutic target, with anti-CD70 antibodies, antibody-drug conjugates (e.g., SGN-CD70A), and chimeric receptor () therapies, including ongoing phase 1/2 trials of ADI-270 and ALLO-316 as of 2025, demonstrating preclinical and clinical efficacy in selectively eliminating CD70-positive tumors while sparing healthy tissues due to its restricted normal expression.

Gene and protein

Gene characteristics

The TNFSF7 gene, which encodes the CD70 protein as a member of the tumor necrosis factor superfamily, is located on chromosome 19p13.3 in humans, spanning approximately 21 kb of genomic DNA from position 6,583,183 to 6,604,103 on the reverse strand (GRCh38 assembly). In mice, the orthologous Cd70 gene resides on chromosome 17, spanning about 4 kb from position 57,452,997 to 57,456,777 on the reverse strand (GRCm39 assembly). The human TNFSF7 gene comprises three s in its canonical transcript, with the coding sequence distributed across these exons to produce a type II . The mouse Cd70 gene features three exons, encoding a similar . The promoter region upstream of the first exon includes binding sites for key transcription factors, notably and AP-1, which drive inducible expression in response to immune activation signals. TNFSF7 exhibits strong evolutionary conservation across mammalian species, with high sequence identity in orthologs from primates (e.g., >95% amino acid similarity to chimpanzee) and rodents (e.g., approximately 57% to mouse), underscoring its preserved role in T-cell costimulation. This conservation extends to the promoter and exon-intron boundaries, facilitating comparable regulatory mechanisms. Mutations in TNFSF7 have been linked to variations in CD70 expression, particularly in primary immunodeficiencies; for instance, homozygous nonsense mutations (e.g., c.535C>T, p.Arg179*) abolish protein expression, resulting in CD70 deficiency and severe impairment of Epstein-Barr virus-specific immunity. Such loss-of-function variants highlight the gene's critical regulatory elements for baseline and induced expression levels.

Protein structure

CD70 is a type II transmembrane glycoprotein belonging to the (TNF) superfamily, encoded by the TNFSF7 gene located on chromosome 19. It consists of a short N-terminal cytoplasmic comprising the first 20 (residues 1–20), a hydrophobic spanning residues 21–41, and a larger extracellular C-terminal domain of approximately 152 (residues 42–193). This topology positions the functional domain on the cell surface for interaction with its receptor. The extracellular domain harbors a TNF homology domain (THD), a conserved typical of TNF superfamily ligands, which spans much of the C-terminal region and enables CD70's biological activity. CD70 assembles into a homotrimer via non-covalent interactions at the THD interfaces, with each protomer adopting a characteristic "jelly-roll" β-sandwich fold composed of two antiparallel β-sheets. This trimeric configuration is essential for ligand presentation and receptor engagement. Structural stability of the CD70 protomer is maintained by intramolecular disulfide bonds, including those between Cys115–Cys151 (linking the DE and GH loops) and Cys128–Cys168 (linking the CD and HI loops), which rigidify the THD and support trimerization. Additionally, an N-linked site at Asn63 (with Thr65) is critical for proper folding, surface expression, and overall protein stability, as its impairs trafficking and functionality. The molecular architecture of CD70 has been elucidated by , as seen in the structure of the CD27–CD70 complex (PDB ID: 7KX0, resolved at 2.69 ), which reveals the THD's close similarity to the canonical TNF fold and confirms the 3:3 of the trimer-receptor assembly.

Expression

In immune cells

CD70 exhibits low or absent basal expression on resting immune cells, including naive T cells and macrophages, under normal physiological conditions. This restricted pattern ensures that CD70 is primarily associated with active immune responses rather than steady-state . Upon stimulation by pathogens or cytokines, CD70 is upregulated on activated antigen-presenting cells (APCs), such as dendritic cells, B cells, and activated T cells. This induction occurs through signaling pathways including (TLR) activation and CD40 ligation, which promote CD70 transcription and surface presentation during immune activation. For instance, mature dendritic cells express CD70 following TLR stimulation, facilitating interactions in lymphoid tissues. The expression of CD70 is transient, typically peaking within 24-48 hours post-activation in cells like plasmacytoid dendritic cells stimulated with CpG ligands, before declining to limit prolonged signaling. Downregulation occurs primarily through transcriptional suppression following interaction with . This mechanism maintains tight temporal control over CD70 availability during immune responses.

In pathological conditions

CD70 expression is frequently dysregulated in pathological states, often exhibiting overexpression or aberrant patterns that deviate from its physiological restriction to activated immune cells. In various cancers, CD70 is overexpressed due to mechanisms such as epigenetic derepression and oncogenic signaling. For instance, in , CD70 is consistently expressed at high levels on both primary and metastatic tumor cells, with minimal presence in normal kidney tissue, positioning it as a tumor-specific marker. Similarly, in hematological malignancies like , CD70 is aberrantly upregulated on malignant B cells, contributing to immune evasion and tumor progression. This overexpression can arise from epigenetic derepression under hypoxic conditions, where hypoxia-inducible factor-2α (HIF-2α) reduces at the CD70 promoter, enhancing transcription and surface expression on cancer cells. Elevated CD70 levels are also observed in autoimmune disorders, notably , where it appears on non-immune cells such as synovial fibroblasts. In patients, fibroblast-like synoviocytes exhibit high CD70 expression, stimulated by proinflammatory cytokines like IL-17 and TNF-α, which promotes T cell activation and sustains chronic synovial inflammation. During chronic infections, dysregulated CD70 signaling contributes to immune exhaustion, though expression patterns can vary by cell type. In models of chronic infection, persistent CD70-CD27 on T cells dampens expansion and effector differentiation, fostering a phenotype akin to exhaustion with reduced functionality. Soluble CD70 can be released from expressing cells and detected in experimental contexts, but in clinical settings, serum levels of soluble CD27—shed following CD70 engagement—correlate with CD70 expression on tumor cells and serve as a for disease progression in lymphomas. For example, in extranodal natural killer/, elevated serum soluble CD27 levels are associated with CD70-positive tumors, detectable via ELISA and indicative of active CD70-CD27 interactions.

Biological functions

Interaction with CD27

CD70 serves as the primary ligand for CD27, a member of the receptor superfamily (TNFRSF7) expressed on T cells, B cells, and natural killer (NK) cells. The interaction occurs through the TNF-like extracellular domain of CD70, which forms a trimer that engages multiple CD27 molecules. The binding affinity between CD70 and CD27 is characterized by an equilibrium dissociation constant (Kd) of approximately 134 nM for the glycosylated form of CD27. This trimeric engagement promotes clustering of CD27 receptors on the cell surface, facilitating multivalent interactions essential for effective . Upon binding, CD27 recruits the adaptor proteins TRAF2 and TRAF5 through its intracellular domain, initiating downstream signaling cascades. These adaptors activate the pathway, promoting transcription of genes involved in cell survival and proliferation, as well as the JNK pathway, which regulates stress responses and . Soluble CD70, often generated by proteolytic shedding, exhibits reduced signaling potency compared to its membrane-bound counterpart, primarily due to the absence of localized presentation that enables efficient receptor clustering. In contrast, membrane-bound CD70 on antigen-presenting cells provides sustained, high-avidity interactions with CD27 on responding lymphocytes.

Roles in adaptive immunity

CD70 plays a critical role in costimulating + T cells during adaptive immune responses, promoting their expansion, effector differentiation, and cytokine production. Through interaction with CD27 on T cells, CD70 signaling enhances the generation of effector + T cells, leading to increased production of interferon-γ (IFN-γ) and improved cytotoxic function. This costimulatory pathway is essential for driving T cell differentiation toward an effector phenotype, as demonstrated in studies where CD70 deficiency results in reduced effector + T cell numbers and impaired antiviral clearance. In B cell responses, CD70 supports survival, activation, and differentiation into s via CD27 expressed on B cells. The CD27-CD70 interaction provides survival signals that prevent in activated B cells and promote their differentiation into antibody-secreting s, enhancing . This pathway is particularly important during reactions, where CD70 on activated T cells or dendritic cells drives and maturation. In vitro and in vivo models have shown that blocking CD27-CD70 signaling impairs B cell expansion and reduces output, underscoring its role in effective antibody responses. CD70 also regulates regulatory T cells (Tregs) to modulate adaptive immunity by limiting their suppressive activity. When expressed on Tregs, CD70 delivers unintended costimulatory signals to conventional T cells via CD27, thereby reducing Treg-mediated suppression and preventing excessive immune inhibition. This mechanism ensures balanced T cell responses, as CD70+ Tregs exhibit diminished suppressive capacity in vitro and promote effector T cell proliferation in vivo. Genetic ablation or blockade of CD70 restores Treg function, highlighting its role in fine-tuning Treg activity during immune challenges. Context-specific effects of CD70 are evident in antiviral immunity, such as during acute virus (LCMV) infection, where it promotes robust + T cell responses. CD70 enhances effector + T cell generation and IFN-γ production, leading to efficient viral clearance in LCMV models. Deficiency in CD70 during acute infection results in lower T cell magnitudes, higher viral loads, and delayed resolution, illustrating its importance in mounting protective adaptive responses against acute viral threats.

Clinical significance

Role in cancer

CD70 was first identified in the 1990s on Reed-Sternberg cells in Hodgkin's , where its expression highlighted a potential role in lymphoid malignancies. Subsequent studies revealed aberrant CD70 overexpression on tumor cells across various cancers, including hematological malignancies like (DLBCL), where it is detected in approximately 70-80% of cases. This overexpression often involves co-expression of CD70 and its receptor CD27 on malignant cells, leading to that promotes tumor , survival, and stemness. In solid tumors, such as , CD70 expression patterns similarly correlate with aggressive disease features, though typically at lower frequencies than in lymphomas. The interaction between CD70 on tumor cells and CD27 on infiltrating T cells contributes to immune evasion by inducing chronic stimulation, which drives T cell exhaustion and , thereby reducing effective tumor-infiltrating (TIL) activity. In glioblastoma, CD70-positive tumors exhibit reduced TIL infiltration and are associated with immunosuppressive microenvironments, including increased M2 presence, further hindering anti-tumor immunity. These mechanisms enable tumor progression, as evidenced by studies showing that CD70 knockdown in glioblastoma models decreases invasiveness and enhances T cell survival. At the molecular level, CD70 signaling activates the pathway via TRAF2/5 adapters, enhancing tumor cell proliferation and conferring resistance to in malignancies like DLBCL. This pathway upregulation supports oncogenesis by promoting survival signals and inhibiting pro-apoptotic factors, with CD70 inhibition observed to induce arrest and in cells. Overall, CD70 overexpression correlates with poor in both hematological and tumors, including shorter survival in patients with high CD70 expression.

Role in autoimmune diseases

In systemic lupus erythematosus (SLE), CD70 overexpression on B cells enhances T cell and sustains autoreactive responses by providing persistent signals through interaction with CD27 on T cells. Single-cell sequencing and RT-qPCR analyses of peripheral from SLE patients have shown significantly higher CD70 transcript levels in s compared to healthy controls, marking a potential novel contributor to B cell dysfunction and autoreactive T cell differentiation in the disease. This is complemented by elevated frequencies of activated CD70+ + T cells in the peripheral of SLE patients, which exhibit effector memory phenotypes and secrete proinflammatory cytokines upon stimulation, thereby amplifying pathological immune activation. In (), CD70 contributes to disease via its expression in synovial tissues, where it drives Th1 and Th17 cell differentiation and proinflammatory production. CD70 is highly upregulated on fibroblast-like synoviocytes in synovial samples, with stimulation (e.g., IL-17 and TNF-α) further increasing its surface expression and promoting the release of IFN-γ and IL-17, which support Th1/Th17 polarization and synovial inflammation. Moreover, CD70+ + T cells are enriched in patients and preferentially produce IFN-γ and IL-17 while expressing the Th17-associated RORγt, exacerbating joint pathology. Animal models highlight CD70's role in driving spontaneous . Transgenic mice constitutively expressing CD70 on B cells, when crossed with myelin oligodendrocyte glycoprotein-specific transgenic mice, develop spontaneous experimental autoimmune encephalomyelitis in about 20% of cases, characterized by infiltration by proinflammatory T cells.

Therapeutic targeting

Monoclonal antibodies

Cusatuzumab (ARGX-110) is a humanized, afucosylated IgG1 that targets the extracellular domain of CD70 with high affinity, engineered to enhance antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP) while blocking the CD70-CD27 interaction to inhibit tumor cell survival signaling. This Fc-domain modification increases binding to FcγRIIa and FcγRIIIa receptors on immune effector cells, promoting targeted elimination of CD70-expressing malignant cells without broadly disrupting normal immune function, as CD70 expression on activated lymphocytes is transient and low-level. In preclinical models, cusatuzumab demonstrated potent antitumor activity against CD70-positive leukemia stem cells and blasts, supporting its evaluation in hematologic malignancies. Clinical development of cusatuzumab has primarily focused on (AML), where CD70 is overexpressed on leukemic blasts and stem cells. In a phase I/II trial (NCT03030612) combining cusatuzumab with in newly diagnosed AML patients ineligible for intensive , the overall response rate (ORR) was 50% in the full analysis set (n=38), with a complete remission (CR) rate of 36.8% and CR with incomplete hematologic recovery (CRi) of 13.2%; at the recommended phase II dose of 10 mg/kg every 3 weeks, ORR reached 37.9%. Median overall survival was 11.5 months, with a 12-month OS rate of 49%, and the combination was generally well-tolerated, with infections and cytopenias as the main adverse events. In the subsequent phase II CULMINATE trial (NCT04023526), cusatuzumab plus yielded CR rates of 12% at 10 mg/kg and 27% at 20 mg/kg (n=103), highlighting dose-dependent efficacy, though higher doses increased grade 3/4 treatment-related adverse events like . Other anti-CD70 monoclonal antibody derivatives, such as antibody-drug conjugates (ADCs), have been explored but faced challenges. SGN-CD70A, an ADC comprising an anti-CD70 antibody conjugated to a pyrrolobenzodiazepine dimer payload via a protease-cleavable linker, was designed to deliver cytotoxic effects specifically to CD70-positive tumor cells through binding to the extracellular domain. Phase I trials (NCT02216890) in CD70-positive malignancies, including renal cell carcinoma and diffuse large B-cell lymphoma, established a maximum tolerated dose of 30 μg/kg every 6 weeks but reported dose-limiting toxicities, including thrombocytopenia (75% incidence) and fatal events like sepsis, leading to discontinuation in the mid-2010s due to unfavorable safety and limited efficacy. As of 2025, cusatuzumab continues in clinical evaluation under OncoVerity, with ongoing phase II trials such as ELEVATE (NCT04150887) assessing its addition to and in treatment-naïve AML, reporting interim CR/CRi rates of 77.3% (n=44) in early data, and expansion into high-risk myelodysplastic syndromes (MDS) through combination regimens to address unmet needs in elderly patients. These efforts underscore cusatuzumab's potential as a leveraging CD70's role in cancer maintenance.

Emerging therapies

Chimeric antigen receptor (CAR) T cells targeting CD70 represent a promising strategy for treating solid tumors, particularly (RCC), where CD70 is overexpressed on tumor cells with limited normal tissue expression. Preclinical studies have demonstrated potent antitumor activity, including complete tumor eradication in subcutaneous xenograft models of CD70-high RCC using allogeneic anti-CD70 CAR T cells at doses of 3 × 10^6 CAR+ cells per mouse. These CAR T cells also showed efficacy in metastatic xenograft models and patient-derived xenografts, with reduced achieved through CD70 in the T cells via TALEN . As of 2025, several CD70-targeted CAR T therapies have entered clinical trials, including ADI-270 (allogeneic Vδ1 γδ CAR T) in phase 1/2 for relapsed/refractory clear cell RCC, showing preclinical potency against CD70-expressing tumors, and CTX130 (CRISPR-edited allogeneic CAR T) in phase 1/2 for , demonstrating safety with in 67% of patients but no dose-limiting toxicities. Building on the clinical successes of CD70-targeting monoclonal antibodies, CAR T approaches aim to enhance T cell persistence and tumor infiltration in solid tumors. Small molecule inhibitors targeting ADAM10, a key metalloproteinase involved in ectodomain shedding of transmembrane proteins including TNF superfamily members, are under investigation to prevent CD70 shedding and maintain its membrane-bound form for immune recognition in cancer. Preclinical data support ADAM10 inhibition as a means to reduce tumor progression by preserving immune-activating ligands on the cell surface, with inhibitors like GI254023X demonstrating reduced shedding in lines. These inhibitors could complement by sustaining CD70 expression on tumor cells. Bispecific antibodies that engage CD70 on tumor cells and CD3 on T cells facilitate T cell redirection and activation, offering a non-cell-based alternative for CD70-positive malignancies. Preclinical evaluations of CD70 × CD3 bispecific constructs have shown robust T cell-mediated against CD70-expressing tumor lines, with optimized formats reducing while enhancing tumor killing. Candidates from biotech pipelines, such as Pfizer's anti-CD3/CD70 bispecific antibody, are in targeting hematologic and solid tumors with high CD70 expression like RCC and . Gene editing approaches using / to knockout the TNFSF7 gene (encoding ) in tumor cells have provided proof-of-concept for reducing CD70-mediated in preclinical models. In 2023 mouse studies, CRISPR-mediated CD70 knockout in cells decreased tumor-induced development and immunosuppressive production (e.g., IL-10, TGF-β), leading to enhanced antitumor immune responses in vivo. Similar knockouts in cell lines confirmed reduced CD70-dependent tumor evasion, supporting potential therapeutic applications to sensitize tumors to blockade. These strategies highlight CRISPR's role in modulating CD70 expression to disrupt tumor-immune interactions.

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