Hubbry Logo
logo
Dimetindene avatar
Dimetindene
Community hub

Dimetindene

logo
0 subscribers
Read side by side
Dimetindene
View on Wikipedia
from Wikipedia
Dimetindene
Clinical data
Trade namesFenistil
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, topical
ATC code
Legal status
Legal status
Identifiers
  • N,N-Dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethan-1-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.024.622 Edit this at Wikidata
Chemical and physical data
FormulaC20H24N2
Molar mass292.426 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • n1ccccc1C(C=3c2ccccc2CC=3CCN(C)C)C
  • InChI=1S/C20H24N2/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20/h4-10,12,15H,11,13-14H2,1-3H3 checkY
  • Key:MVMQESMQSYOVGV-UHFFFAOYSA-N checkY
  (verify)

Dimetindene, also sold under the brand name Fenistil, is an antihistamine/anticholinergic. It is a first generation[1] selective H1 antagonist.[2] Dimetindene is an atypical first generation H1 antagonist as it only minimally[3] passes across the blood–brain barrier.

Dimetindene is also an M2 receptor antagonist.[4]

It was patented in 1958 and came into medical use in 1960.[5]

Medical use

[edit]

Dimetindene is used orally and topically as an antipruritic.[6] It is used topically to treat skin irritations, such as insect bites. Dimetindene is also administered orally to treat allergies, such as hay fever.

It is commonly formulated as its maleic acid salt, dimethindene maleate.

Names

[edit]

It is sold under the brand name Fenistil among others.

References

[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

Dimetindene

View on Grokipedia
from Grokipedia
Dimetindene, also known as Dimetindene maleate in its common salt form, is a first-generation H1-receptor antihistamine and anticholinergic agent primarily used for the symptomatic treatment of allergic reactions, including urticaria, allergic rhinitis, and pruritus associated with conditions such as insect bites or dermatoses.[1] It acts as a selective antagonist at histamine H1 receptors, blocking the effects of endogenous histamine to alleviate symptoms like itching, swelling, and nasal congestion, and is administered via oral, topical, or intranasal routes under the brand name Fenistil.[2] Patented in 1958 and introduced to medical use in 1960, it is primarily available in various European countries. As a sedating antihistamine, it exhibits moderate potency with a prolonged duration of action, making it suitable for both acute and extended relief in adults and children over certain ages.[3][4] Pharmacologically, dimetindene demonstrates strong affinity for H1 receptors, with studies showing effective inhibition of histamine-induced weal and flare responses in skin prick tests, reducing symptoms for up to 16 hours or more after dosing.[5][6] Its anticholinergic properties contribute to additional antipruritic effects, and it has been evaluated for local anesthetic activity in topical applications, though this is secondary to its primary antihistaminic role.[7] The drug is well-absorbed orally and intranasally, with pharmacokinetics indicating rapid onset and bioavailability suitable for both systemic and localized therapy, though it is nationally authorized in various European countries rather than centrally approved by the EMA.[8][9] Common side effects include sedation due to its first-generation classification, along with potential skin or respiratory irritation in topical forms, and it is contraindicated in certain populations like those with glaucoma or prostate hypertrophy owing to anticholinergic risks.[3] Clinical trials up to phase IV have supported its efficacy and safety, particularly in pediatric nasal spray formulations for allergic rhinitis, where it significantly reduces symptoms without major adverse events.[10] Despite its established use since the late 20th century, dimetindene remains a targeted option for allergy management where non-sedating alternatives are unsuitable.[7]

Medical uses

Indications

Dimetindene is primarily indicated for the symptomatic relief of allergic reactions, including urticaria (hives), hay fever (allergic rhinitis), perennial rhinitis, food allergies, and drug allergies.[11][12] It is also approved for the treatment of pruritus associated with insect bites and eruptive skin diseases such as chickenpox.[12] These indications stem from its role as a first-generation H1 antihistamine that effectively alleviates itching, rash, and other histamine-mediated symptoms in mild to moderate allergic conditions.[13] In addition to its primary uses, dimetindene serves as an adjunctive therapy in allergic dermatoses, such as eczema and contact dermatitis, where it helps manage persistent itching and inflammation alongside other treatments.[12] For localized symptoms, topical formulations like gels are applied directly to affected skin areas to provide rapid relief from pruritus caused by insect bites, sunburn, or minor allergic irritations.[11] Oral and nasal preparations, including drops and sprays, are utilized for systemic relief of upper respiratory allergy symptoms, such as those in hay fever or perennial rhinitis, offering broad coverage for non-localized reactions.[14][12] Clinical guidelines in non-US markets, particularly in Europe and Asia, classify dimetindene as a first-line therapy for mild to moderate allergic reactions due to its efficacy and favorable safety profile in outpatient settings.[13][15] Its sedative properties may further aid in managing sleep disturbances associated with allergy-related discomfort, though this is secondary to its antihistaminic effects.[11]

Administration and dosage

Dimetindene is available in multiple formulations for oral, topical, and nasal administration, allowing targeted treatment based on the condition's location and severity.[11] For systemic effects, dimetindene is administered orally via tablets or drops (syrup equivalent). The standard adult dosage is 1–2 mg three times daily, corresponding to one or two 1 mg tablets or 20–40 drops (1 mg/mL solution) three times daily.[16][17] In pediatric patients from 1 month of age (under medical advice for infants under 1 year), the dosage is generally 0.1 mg/kg body weight per day, divided into three doses; for children aged 1–3 years (e.g., 10 kg child), this corresponds to approximately 7 drops (0.35 mg) three times daily (total 1 mg daily). Dosages may vary by region and product.[17][18] Topical administration uses a 0.1% gel or cream applied directly to pruritic skin areas two to four times daily, massaging lightly to promote absorption, for localized relief in conditions like urticaria.[19][20] Nasal formulations combine dimetindene (0.25 mg/mL) with a decongestant such as phenylephrine (2.5 mg/mL), as in products like Vibrocil nasal spray, for allergic rhinitis. These combination nasal sprays are suitable for children from 6 years of age (under adult supervision) and are not recommended for children under 6 years, for whom nasal drops may be available (typically for ages 2-6). For children aged 6 to 12 years, the recommended dosage is 1 spray in each nostril 3–4 times daily, with at least 6 hours between applications. For adolescents over 12 years of age and adults, 2 sprays per nostril 3–4 times daily. Pure dimetindene nasal formulations, if available, may have different dosing recommendations.[21][22][23] Treatment duration is generally short-term, limited to 7 days for nasal formulations containing a decongestant to prevent rebound congestion, or 7–10 days for other formulations, to minimize risks such as tolerance in nasal use or sedation accumulation.[20][21] In elderly patients or those with hepatic impairment, dosages should be reduced or administered cautiously due to potential altered metabolism and increased sensitivity to sedative effects.

Adverse effects

Common side effects

The most common side effect of oral dimetindene maleate is sedation or drowsiness, reported in up to 22% of patients overall, with tiredness and sleepiness being the most frequent adverse events, particularly in those prone to fatigue (51% incidence in susceptible individuals versus 17% in others).[24] This sedative effect arises from its first-generation H1 receptor antagonism, which allows penetration of the blood-brain barrier.[11] Other frequently observed effects include dry mouth or throat, dizziness, nausea, agitation, and headache, typically occurring at the start of treatment and resolving with continued use.[17] Anticholinergic effects such as dry mouth and constipation are also common, alongside occasional blurred vision and gastrointestinal upset like nausea or vomiting.[25] In children, paradoxical excitation may occur instead of sedation, manifesting as irritability or hyperactivity.[26] For topical formulations, mild and transient skin reactions at the application site, including burning sensation, dry skin, or erythema, are the most reported adverse effects, reported in post-marketing surveillance.[19] Management of these side effects generally involves dose reduction to mitigate sedation, and patients are advised to avoid driving or operating machinery until the effects are known, as dimetindene can impair concentration and reaction time.[17]

Contraindications and precautions

Dimetindene is contraindicated in patients with hypersensitivity to the active substance or any excipients.[27] It is also absolutely contraindicated in individuals with narrow-angle glaucoma due to its anticholinergic effects, which can exacerbate intraocular pressure.[27] Similarly, it should not be used in patients experiencing urinary retention associated with prostate enlargement (urethroprostatic disorders), as the drug's antimuscarinic properties may worsen obstruction.[28] Use with caution in patients with epilepsy, as dimetindene may lower the seizure threshold and potentially precipitate convulsions.[29] Precautions are advised during pregnancy; use only if the expected benefit to the mother outweighs the potential risk to the fetus, and generally avoid during the first trimester to minimize potential risks.[27] In breastfeeding women, dimetindene is excreted in small amounts into breast milk, and its use is not recommended due to the risk of infant sedation; if necessary, close monitoring of the infant for drowsiness is required.[27] Elderly patients require caution owing to heightened sensitivity to anticholinergic effects, which may lead to confusion, constipation, or urinary issues.[28] For children under 1 year, dimetindene should be used with extreme caution because of the potential for excitation or severe sedative effects, including episodes of sleep apnea.[27] Overdose poses significant risks, particularly in children, where the minimum toxic dose is approximately 0.5 mg/kg body weight, leading to symptoms such as severe central nervous system sedation or stimulation, tachycardia, and hallucinations.[3] Treatment of overdose is supportive, focusing on gastrointestinal decontamination with activated charcoal, monitoring vital signs, and managing symptoms like hypotension with vasopressors if needed; no specific antidote exists.[27] Drug interactions must be considered, as dimetindene enhances sedation when combined with central nervous system depressants such as alcohol or opioids.[27] Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated due to potentiated antimuscarinic and central nervous system depressant effects.[27]

Pharmacology

Pharmacodynamics

Dimetindene exerts its primary therapeutic effects through competitive antagonism at the histamine H1 receptor, where it binds with high affinity (Ki = 1.5 nM), thereby inhibiting the actions of endogenous histamine. This blockade prevents histamine-mediated responses, including vasodilation, increased vascular permeability leading to edema, pruritus, and bronchoconstriction, which are central to allergic reactions.[30] The drug's potency at the H1 receptor is evidenced by a pA2 value of 9.12 in vascular smooth muscle preparations, comparable to that of other first-generation antihistamines such as clemastine (pA2 = 9.31), indicating strong inhibitory activity against histamine-induced contractions.[31] In addition to its H1 antagonism, dimetindene demonstrates secondary activity as an antagonist at muscarinic acetylcholine receptors, particularly the M2 subtype via its (S)-(+)-enantiomer, with a binding affinity of pKi = 7.78 (Ki ≈ 17 nM). The (R)-(-)-enantiomer is the eutomer for H1 receptor binding, while the (S)-(+)-enantiomer shows selectivity for M2 over other muscarinic subtypes (M1, M3, M4).[11][32] This muscarinic blockade contributes to anticholinergic effects, such as dry mouth and potential urinary retention, though its affinity is approximately 11-fold lower than for H1 receptors.[30] As a first-generation H1 antagonist, dimetindene is lipophilic and crosses the blood-brain barrier, resulting in central H1 receptor blockade that manifests as sedation and drowsiness. It lacks significant activity at H2 or other histamine receptor subtypes, underscoring its selectivity within the H1 class.[11][33] The onset of antihistaminic action is rapid, typically within 15-30 minutes after oral or topical administration, with effects peaking around 5 hours and lasting up to 12-16 hours.[11][4]

Pharmacokinetics

Dimetindene is well absorbed following oral administration, with a systemic bioavailability of approximately 70%. Peak plasma concentrations are reached within 2 hours, and the onset of action occurs within 30 minutes, with maximal effects observed around 5 hours post-dose. Topical application results in rapid penetration for local antipruritic effects, but systemic absorption is minimal, with less than 0.03% of the applied dose excreted unchanged or as metabolites in urine over 32 hours. The nasal route provides a quick systemic onset due to rapid mucosal absorption, supporting its use in allergic rhinitis.[34][35][36] The drug is widely distributed throughout the body, including the central nervous system, owing to its lipophilic nature as a first-generation antihistamine. The apparent volume of distribution is approximately 2.16 L/kg, indicating moderate tissue penetration. Plasma protein binding is high, at about 90% over therapeutic concentrations of 0.09–2 μg/mL.[37][34] Dimetindene undergoes hepatic metabolism primarily through hydroxylation and methoxylation to form inactive metabolites including 6-hydroxydimethindene and 6-hydroxy-N-demethyldimethindene, which are often conjugated with glucuronic or sulfuric acid.[38][39][34] Elimination occurs mainly via renal excretion of metabolites, with 5–10% of the dose eliminated unchanged in the urine; biliary excretion also contributes. The elimination half-life in adults is 4–6 hours, supporting twice-daily dosing without significant accumulation during short-term use. Clearance is approximately 4.83 mL/min/kg.[34][37][38] In special populations, clearance is reduced in hepatic impairment due to the drug's reliance on hepatic metabolism, necessitating dose adjustments. The half-life may be prolonged in the elderly, consistent with age-related declines in hepatic and renal function observed in first-generation antihistamines. Specific adjustments in children are guided by weight-based dosing.[40][33]

Chemistry

Structure and properties

Dimetindene, also known as dimethindene, is an organic compound with the molecular formula C₂₀H₂₄N₂ for the free base form. The commonly used maleate salt has the formula C₂₄H₂₈N₂O₄, formed as a 1:1 salt with maleic acid. Its IUPAC name is N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine, and the molecular weight is 292.4 g/mol for the base and 408.5 g/mol for the maleate salt. The chemical structure of dimetindene features an indene core, a bicyclic system consisting of a benzene ring fused to a cyclopentene ring. At the 2-position of the indene, a dimethylaminoethyl side chain (-CH₂CH₂N(CH₃)₂) is attached, while the 3-position bears a 1-(pyridin-2-yl)ethyl substituent (-CH(CH₃)-C₅H₄N).[41] This arrangement, with the pyridine ring and tertiary amine, contributes to its selectivity as an H₁ receptor antagonist.[11] Dimetindene maleate appears as a white to off-white crystalline powder.[42] It has a melting point of 159–161 °C and is slightly soluble in water but soluble in methanol.[42] The compound is stable under normal storage conditions, with no significant degradation reported when kept in a cool, dry environment.[43] As a first-generation antihistamine, dimetindene is classified within the alkylamine subclass and exhibits lipophilicity that facilitates membrane permeability.[11][2] This property supports its pharmacological activity, including central nervous system penetration.[11]

Synthesis

Dimetindene, a selective histamine H1 receptor antagonist, was first synthesized through a multi-step process patented in 1958 by Ciba Pharmaceutical Products, Inc.[44] The original synthesis begins with the preparation of benzyl malonic diethyl ester via the alkylation of diethyl malonate with benzyl chloride using sodium ethoxide in ethanol under reflux conditions, establishing the indane precursor framework through subsequent cyclization.[45] The next key step involves nucleophilic substitution by alkylating the benzyl malonic diethyl ester with 2-chloro-N,N-dimethylethan-1-amine in the presence of sodium hydride, introducing the N,N-dimethylaminoethyl side chain at the alpha position; this reaction is conducted in toluene at reflux to yield the substituted malonate intermediate with approximately 63% efficiency under conventional conditions.[45] Saponification of this intermediate follows using sodium hydroxide in ethanol-water at reflux, followed by acidification and decarboxylation to form the corresponding carboxylic acid. This acid then undergoes intramolecular Friedel-Crafts acylation with polyphosphoric acid at elevated temperatures, cyclizing to produce 2-(2-dimethylaminoethyl)indan-1-one, the critical ketone intermediate, though with modest yields around 20% in the original process.[45] The final assembly of the dimetindene core proceeds via nucleophilic addition of the lithium salt derived from 2-ethylpyridine (lithiated at the alpha-methyl position with n-butyllithium) to the indan-1-one ketone at low temperature (-78°C) in diethyl ether, forming a tertiary alcohol intermediate. Dehydration of this alcohol is achieved by heating with 20% hydrochloric acid at reflux, yielding the indene double bond and the 3-[1-(pyridin-2-yl)ethyl] substituent, resulting in racemic dimetindene base with about 60% yield in this step.[45] The overall process from diethyl malonate affords dimetindene in 4-5% yield, involving harsh conditions and volatile organic solvents, though industrial adaptations have aimed to improve efficiency through purification steps like distillation and salt formation with maleic acid to enhance stability and solubility.[45][44]

History

Development

Dimetindene was developed in the 1950s by researchers at Ciba Pharmaceutical Products, Inc., a Swiss firm, as part of efforts to advance first-generation H1 antihistamines following prototypes like diphenhydramine introduced in the 1940s.[46][44] The compound, chemically a derivative of indene with a pyridine substituent, was patented under US Patent 2,970,149, filed on November 3, 1958, and emphasizing improved H1 receptor selectivity and lower toxicity compared to prior agents.[44] Preclinical evaluations in the late 1950s included animal studies confirming anti-allergic efficacy, such as antagonism of histamine-induced contractions in isolated guinea pig ileum (pA2 = 8.9), alongside low acute oral toxicity in rats (LD50 = 618 mg/kg).[47][48] Initial clinical trials in the early 1960s assessed dimetindene for conditions like pruritus and allergic rhinitis, demonstrating effective symptom relief with a sedating profile that supported its suitability for nighttime administration.[49][47]

Regulatory approval

Dimetindene was initially approved for medical use in Europe in 1960, with early authorizations in countries such as Switzerland and Germany under the brand name Fenistil, developed by Ciba (later part of Novartis). Fenistil was first launched in 1968.[11][50] The drug has not received approval from the United States Food and Drug Administration (FDA), where it is classified as an unapproved drug, and no New Drug Application (NDA) has been filed for it.[11] Internationally, dimetindene is approved in the European Union through national authorizations by the European Medicines Agency (EMA), as well as in Canada and Australia, where it is available for oral and topical use as an antihistamine.[51] It is classified under Anatomical Therapeutic Chemical (ATC) codes R06AB03 for systemic use as an oral/topical antihistamine and D04AA13 for topical use as an antipruritic agent.[52][53] Regarding pregnancy and lactation, animal reproduction studies have shown no evidence of fetal harm, though adequate human studies are lacking; it is recommended only if the potential benefit justifies the potential risk to the fetus.[13] For pediatric use, topical formulations are approved from 1 month of age, while oral drops require medical supervision for infants under 1 year but are approved from that age onward in approved jurisdictions.[18] As of 2025, there have been no major regulatory withdrawals of dimetindene, though ongoing pharmacovigilance includes monitoring for pediatric toxicity thresholds, with the minimum toxic dose estimated at 0.5 mg/kg body weight based on case reports of accidental ingestions.[3]

Society and culture

Brand names

Dimetindene is primarily marketed under the brand name Fenistil by Novartis and GlaxoSmithKline in various formulations, including 0.1% gel for topical use, 0.1 mg/ml oral drops, emulsion, and 1 mg tablets, and is available in over 50 countries across Europe, Asia, Latin America, the Middle East, and Africa.[51][11] Vibrocil is another notable brand, formulated as a nasal combination product with phenylephrine for relief of nasal congestion and allergies, and is distributed by Novartis and GlaxoSmithKline in countries such as Egypt, Lebanon, Hungary, Lithuania, Portugal, Romania, Malta, Peru, and South Africa.[51] Additional brand names include Betiden (by Belupo in Bosnia & Herzegovina), Dermacutan (by Santa-Farma in Turkey), Fenistil 24 (by Novartis in Finland and Lithuania), and Grivix (by Medana in Latvia and Lithuania).[51] Dimetindene maleate is available as a generic drug in the European Union, select Asian markets, and Latin American countries, but it lacks approval from the U.S. Food and Drug Administration, resulting in no generic or branded versions in the United States.[51][11]

Availability

Dimetindene is widely available in Europe, the Middle East, Asia, and Africa, with formulations marketed in countries including Bosnia and Herzegovina, Cyprus, Egypt, Latvia, Lebanon, the Netherlands, Peru, Malta, Russia, Jordan, China, and India.[54][55][56][57] Topical forms, such as gels and creams, are often sold over-the-counter (OTC) in many of these regions for symptomatic relief, while oral formulations typically require a prescription due to potential sedative effects.[58][59] The drug is not marketed in the United States, where no direct equivalents are approved for consumer use, nor in Japan, despite some pharmaceutical exports to the region.[51] In the United Kingdom, availability remains limited following post-Brexit regulatory alignments, with restricted access compared to broader European distribution.[51] Generic dimetindene is inexpensive, typically costing $5–10 per pack of tablets or drops, and is commonly formulated in combination products with decongestants for cold and allergy relief.[60][61] As of 2025, supply chains for dimetindene remain stable globally, with no reported shortages, though pediatric formulations like oral drops are subject to ongoing safety monitoring by health authorities.[62][63] Dimetindene holds no controlled substance scheduling in major jurisdictions, classifying it as a non-restricted medication for human use.[64] Veterinary applications are limited, primarily relying on analogous first-generation antihistamines for managing allergic conditions in animals like dogs, with dimetindene itself used off-label in some studies for atopic dermatitis.[65]

References

  1. (+-)-Dimethindene | C20H24N2 | CID 21855 - PubChem
  2. Dimetindene H1-Antihistamine Action | Pathway - PubChem
  3. Dimetindene-Is the minimum toxic dose for children too strict?
  4. Effect-kinetic Characterization of Dimethindene Maleate Following ...
  5. Comparative effect of dimethindene maleate and chlorpheniramine ...
  6. Dose-related control of allergic rhinitis symptoms by a H1 ... - PubMed
  7. Evaluation of the local anaesthetic activity of dimetindene maleate ...
  8. Pharmacokinetics of dimetindene after intravenous and oral ...
  9. [XLS] Worksheet 1 - European Medicines Agency
  10. Efficacy and safety of intranasally applied dimetindene maleate ...
  11. Dimetindene: Uses, Interactions, Mechanism of Action - DrugBank
  12. (+-)-Dimethindene | C20H24N2 | CID 21855 - PubChem
  13. Dimetindene - an overview | ScienceDirect Topics
  14. Efficacy and tolerability of intranasally applied dimetindene maleate ...
  15. Guideline for acute therapy and management of anaphylaxis
  16. Dimethindene: Uses, Dosage, Side Effects and More - MIMS Malaysia
  17. [PDF] SUMMARY OF PRODUCT CHARACTERISTICS (SmPC)
  18. Fenistil Drops
  19. [PDF] Summary of Product Characteristics - HPRA
  20. Fenistil Gel
  21. [PDF] Vibrocil - NET
  22. [PDF] Page 3 Vibrocil
  23. Vibrocil nasal spray - Gurkerl.at
  24. [Prescription and safety of dimethindene maleate micropellet ...
  25. What are the side effects of Dimetindene Maleate? - Patsnap Synapse
  26. Dimethindene: Uses, Dosage, Side Effects and More - MIMS Malaysia
  27. [PDF] DIMESTIL
  28. Dimethindene - Indications, Dosage, Side Effects and Precautions
  29. Effects of dimethindene maleate (Fenistil®) on histaminic, muscarinic and serotoninergic receptor systems - Inflammation Research
  30. https://link.springer.com/article/10.1007/BF01997387
  31. H1 Antihistamines: Current Status and Future Directions - PMC
  32. [PDF] FENISTIL® DROPS - NET
  33. Transdermal absorption of dimethindene in man - PubMed
  34. Effects of dimethindene maleate nasal spray on the quality of life in ...
  35. dimetindene - Drug Central
  36. [PDF] Dr. Carolina Diamandis1, Helmut Kaucher2, Sven Stoltenberg2 ...
  37. Enantioselective biotransformation of the chiral antihistaminic drug ...
  38. dimethindene | Dosing & Uses - medtigo
  39. dimetindene | C20H24N2 - ChemSpider
  40. DIMETHINDENE MALEATE | 3614-69-5 - ChemicalBook
  41. https://sds.edqm.eu/pdf/SDS/EDQM_201600299_1.0_SDS_EN.pdf
  42. https://patents.google.com/patent/US2970149A/en
  43. Green Solvents for Eco-Friendly Synthesis of Dimethindene - NIH
  44. Histamine pharmacology: from Sir Henry Dale to the 21st century
  45. https://doi.org/10.1016/0041-008X(61
  46. Investigation of the antihistaminic action of dimethindene maleate ...
  47. Clinical use of a new antihistaminic drug: dimethpyrindene - PubMed
  48. Dimetindene - Drugs.com
  49. https://atcddd.fhi.no/atc_ddd_index/?code=R06AB03
  50. https://atcddd.fhi.no/atc_ddd_index/?code=D04AA13
  51. Fenistil (International database) - Drugs.com
  52. Vibrocil (International database) - Drugs.com
  53. Dimetindene Maleate Imports in World - Volza.com
  54. Dimetindene Maleate Market Opportunities Worldwide - LinkedIn
  55. Substances for countries - OTC Ingredients - AESGP
  56. [PDF] The Egyptian Non-prescription Medicinal Products (OTC) List 2021
  57. dimetindene maleate Oral drops 1 mg/1 ml - Pipelinepharma
  58. Buy Dimetindene 1mg Tablets Online | IDM - InternationalDrugMart
  59. Drug Shortages List - ASHP
  60. Drug Shortages - FDA
  61. [PDF] Controlled Substances - Alphabetical Order
  62. Efficacy of dimetinden and hydroxyzine/chlorpheniramine in atopic ...
  63. Vibrocil Nasal Spray Product Information
User Avatar
No comments yet.