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Lactitol
Lactitol
Lactitol
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Lactitol
Clinical data
Trade namesImportal, Pizensy, Lacty
Other namesLactitol Hydrate (JAN JP)
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
  • 4-O-α-D-Galactopyranosyl-D-glucitol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E numberE966 (glazing agents, ...) Edit this at Wikidata
CompTox Dashboard (EPA)
ECHA InfoCard100.008.698 Edit this at Wikidata
Chemical and physical data
FormulaC12H24O11
Molar mass344.313 g·mol−1
3D model (JSmol)
Melting point146 °C (295 °F)
  • C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@H]([C@@H](CO)O)[C@@H]([C@H](CO)O)O)O)O)O)O
  • InChI=1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8-,9-,10+,11+,12-/m0/s1
  • Key:VQHSOMBJVWLPSR-JVCRWLNRSA-N

Lactitol is a disaccharide sugar alcohol produced from lactose. It is used as a replacement bulk sweetener for low calorie foods with 30–40% of the sweetness of sucrose. It is also used medically as a laxative.

Production

[edit]

Lactitol is produced by hydrogenation of lactose using Raney nickel catalyst. The product can be obtained as an anhydrous, monohydrate, or dihydrate. Two manufacturers, Danisco and Purac Biochem, produce about 10,000 tons/y.[1]

Applications

[edit]

Lactitol is used in a variety of low food energy or low fat foods. High stability makes it popular for baking. It is used in sugar-free candies, cookies (biscuits), chocolate, and ice cream, with a sweetness of 30–40% that of sucrose.[2] Lactitol also promotes colon health as a prebiotic. Because of poor absorption, lactitol only has 2–2.5 kilocalories (8.4–10.5 kilojoules) per gram,[2] compared to 4 kilocalories (17 kJ) per gram for typical saccharides. Hence, lactitol is about 60% as caloric as typical saccharides.

Medical

[edit]

Lactitol is listed as an excipient in some prescription drugs.[3][4]

Lactitol is a laxative and is used to prevent or treat constipation,[5] e.g., under the trade name Importal.[6][7]

In February 2020, Lactitol was approved for use in the United States as an osmotic laxative for the treatment of chronic idiopathic constipation (CIC) in adults.[8][9][10]

Lactitol in combination with Ispaghula husk is an approved combination for idiopathic constipation as a laxative and is used to prevent or treat constipation.[medical citation needed]

Safety and health

[edit]

Lactitol, erythritol, sorbitol, xylitol, mannitol, and maltitol are all classified sugar alcohols (lactitol and maltitol are in fact disaccharide alcohols, since they contain one intact sugar).[1] The U.S. Food and Drug Administration (FDA) classifies sugar alcohols as "generally recognized as safe" (GRAS).[medical citation needed] They are approved as food additives, and are recognized as not contributing to tooth decay or causing increases in blood glucose.[medical citation needed] Lactitol is also approved for use in foods in most countries around the world.[medical citation needed]

Like other sugar alcohols, lactitol causes cramping, flatulence, and diarrhea in some individuals who consume it. These effects arise because humans lack a suitable beta-galactosidase in the upper gastrointestinal (GI) tract, and a majority of ingested lactitol reaches the large intestine,[11] where it then becomes fermentable to gut microbes (prebiotic) and can pull water into the gut by osmosis.[medical citation needed] For these reasons, medical advice is often sought before their use.

History

[edit]

The U.S. Food and Drug Administration (FDA) approved Pizensy based on evidence from a clinical trial (Trial 1/ NCT02819297) of 594 subjects with CIC conducted in the United States.[10] The FDA also considered other supportive evidence including data from Trial 2 (NCT02481947) which compared Pizensy to previously approved drug (lubiprostone) for CIC, and Trial 3 (NCT02819310) in which subjects used Pizensy for one year as well as data from published literature.[10]

The benefit and side effects of Pizensy were evaluated in a clinical trial (Trial 1) of 594 subjects with CIC.[10] In this trial, subjects received treatment with either Pizensy or placebo once daily for 6 months.[10] Neither the subjects nor the health care providers knew which treatment was being given until after the trials were completed.[10]

In the second trial (Trial 2) of three months duration, improvement in CSBMs was used to compare Pizensy to the drug lubiprostone which was previously approved for CIC.[10] The third trial (Trial 3) was used to collect the side effects in subjects treated with Pizensy for one year.[10]

References

[edit]
[edit]
Revisions and contributorsEdit on WikipediaRead on Wikipedia

Lactitol

View on Grokipedia
from Grokipedia
Lactitol is a , chemically known as 4-O-β-D-galactopyranosyl-D-glucitol, produced by the catalytic of . It exists in various crystalline forms, including monohydrate, dihydrate, and anhydrous variants, and is characterized by its white, crystalline powder appearance, mild sweetness at 30-40% that of , and a caloric value of approximately 2.0-2.4 kcal/g. As a non-reducing , lactitol is stable across a wide range (3-9) and does not participate in Maillard reactions, making it suitable for heat-processed foods. First synthesized in the through processes using catalysts like or , lactitol has grown into a commercially significant . In the , it serves as a bulk , , and texturizer in products such as chocolates, gums, baked goods, and low-calorie desserts, where it provides bulk and similar to while contributing fewer calories and a lower , benefiting diabetics and supporting prebiotic effects by promoting beneficial gut bacteria like Bifidobacteria. Its non-cariogenic nature also helps prevent dental caries. Pharmaceutically, lactitol functions as an osmotic laxative for treating chronic idiopathic constipation in adults, drawing water into the intestines to facilitate bowel movements with minimal systemic absorption, and is marketed under names like Pizensy, approved by the FDA in 2020. It is also used as an excipient in drug formulations, including as a cryoprotectant and in tablet production. The U.S. Food and Drug Administration has classified lactitol as generally recognized as safe (GRAS) for food use since 1993, with an acceptable daily intake not specified due to its safety profile, though doses exceeding 20 g/day may cause laxative effects. Animal toxicity studies indicate low acute toxicity, with LD50 values exceeding 23 g/kg in mice and 30 g/kg in rats.

Chemical Properties

Molecular Structure

Lactitol is a with the molecular formula C12H24O11. It consists of a β-D-galactopyranose unit linked to a D-glucitol () unit through a β-1,4-glycosidic bond, where the anomeric carbon (C1) of the is bonded to the oxygen at the C4 position of the glucitol chain. This structure arises from the of , the parent with formula C12H22O11, which comprises β-D-galactopyranosyl-(1→4)-D-glucose. In , the glucose unit features a reducing group at C1; reduces this to a (CH2OH), transforming the glucose into an acyclic glucitol moiety and yielding the non-reducing lactitol molecule. The resulting structure maintains the intact β-D-galactopyranose ring—characterized by hydroxyl groups at C2, C3, C4 (axial), and C6, with the glycosidic linkage at C1—while the glucitol chain is a linear six-carbon with hydroxyl groups on all carbons, conferring lactitol's polyol properties. This alteration from a reducing to a non-reducing form distinguishes lactitol chemically from .

Physical Characteristics

Lactitol appears as a white to off-white crystalline powder, available in both and monohydrate forms, with the monohydrate being the most commonly used in commercial applications due to its stability. The form consists of crystals obtained from absolute , while the monohydrate is a white, odorless, sweet crystalline solid. Lactitol exhibits high solubility in water, with approximately 206 g dissolving per 100 g at 25°C for the monohydrate form, making it suitable for aqueous formulations. It is sparingly soluble in , at about 0.75 g per 100 g solvent at 25°C, and slightly soluble in . The melting point varies by hydration state: the anhydrous form melts at 146°C, while the monohydrate form has a melting range of 94–97°C, often accompanied by . Lactitol is hygroscopic in its form but non-hygroscopic as the monohydrate, which influences its handling and storage under controlled humidity. The compound exists in various crystal forms, including , monohydrate, and dihydrate, each with distinct properties affecting processing. Its is predicted at 1.69 g/cm³, and it displays a positive of +14° (c = 4 in water at 23°C) for the anhydrous form, ranging from +12.3° to +15.0° for hydrated variants. These characteristics stem from its alcohol structure, contributing to its utility in formulations requiring specific flow and dissolution behaviors.

Stability and Reactivity

Lactitol demonstrates high thermal stability, remaining intact during temperatures up to 180°C and decomposing only above 200°C, where it shows only slight color changes without significant breakdown. This stability is enhanced by the absence of a reducing , preventing participation in Maillard reactions that would otherwise lead to unwanted flavor or color development during heating. In terms of pH stability, lactitol maintains its structure across a broad range from 3 to 9, rendering it suitable for incorporation into acidic food products such as beverages and without degradation. Its reactivity with other compounds is minimal; unlike reducing sugars, lactitol exhibits a low tendency for browning or under or alkaline conditions, due to its non-reducing nature, which avoids oxidative or condensative reactions common in monosaccharides and disaccharides. For shelf-life considerations, lactitol offers a exceeding three years under standard conditions of 25°C and 60% relative . It is resistant to fermentation by cariogenic oral , contributing to its non-cariogenic properties, while being selectively fermented by beneficial such as Bifidobacteria as a prebiotic. This selectivity, combined with its low hygroscopicity compared to other polyols, helps prevent excessive moisture absorption and maintain product crispness in applications like and baked goods, supporting extended storage periods. Crystalline forms may still require controlled to avoid hydrate transitions that could affect texture.

Production

Synthesis from Lactose

Lactitol is primarily synthesized through the catalytic of , a composed of and glucose, where the group at the reducing end of the glucose moiety is reduced to a primary hydroxyl group, yielding the corresponding . This reduction transforms (C₁₂H₂₂O₁₁) into lactitol (C₁₂H₂₄O₁₁) by the addition of , as represented by the simplified reaction :
\ceC12H22O11+H2−>C12H24O11\ce{C12H22O11 + H2 -> C12H24O11}
The process follows the principles of , adhering to Langmuir-Hinshelwood-Hougen-Watson kinetics, where and adsorb onto the catalyst surface, undergo surface reaction (the rate-determining step), and desorb as lactitol. In laboratory-scale experiments, this is typically performed in batch reactors to study kinetics and selectivity, allowing precise control over variables to achieve high conversion rates. Common catalysts for this hydrogenation include (a sponge nickel variant, often promoted with ) and supported ruthenium catalysts such as or , with the latter offering superior selectivity and resistance to deactivation compared to nickel-based options. The reaction is conducted under elevated temperatures of 100–130°C and pressures of 20–70 bar to facilitate activation and in the aqueous solution, ensuring near-complete conversion (yields exceeding 98%) within hours. Optimal conditions, such as a catalyst loading of 1.5–2.5 wt% relative to and a lactose concentration of around 40 wt% in , minimize side reactions while maintaining process efficiency in lab settings. Incomplete hydrogenation or suboptimal conditions can lead to minor byproducts, including (from glucose reduction), galactitol (from reduction), (via ), and lactulitol or (from or ). These byproducts typically constitute less than 2% of the reaction mixture under controlled laboratory conditions, with selectivity for lactitol enhanced by higher and lower temperatures to suppress pathways. Catalyst deactivation, often due to poisoning by or protein residues from impurities, is a key consideration in lab-scale studies, necessitating regeneration techniques like washing to restore activity.

Industrial Processes

Lactitol is primarily manufactured using derived from permeate, a of the industry generated during cheese and . This feedstock links lactitol production directly to global dairy output, with global production exceeding 190 million tons annually worldwide, providing over 9 million tons of availability. The industrial process begins with the catalytic of a 30-50% aqueous solution in continuous stirred-tank reactors, employing or sponge nickel catalysts at temperatures of 130-180°C and pressures of 50-170 bar. Following , the reaction mixture undergoes filtration to separate the spent catalyst, ion-exchange purification to remove ionic impurities and minor byproducts such as lactulitol and , and concentration via . The purified solution is then subjected to controlled cooling , typically from 70°C to 40°C, to yield lactitol monohydrate crystals, which are separated, washed, and dried for commercial use. This process achieves high efficiency, with lactose conversion rates typically exceeding 95% and overall yields up to 98% in optimized continuous systems. Energy considerations are critical for , as the high-temperature and high-pressure step accounts for a significant portion of the input; modern implementations incorporate catalyst recycling and heat recovery to reduce consumption and operational costs. Major producers of lactitol include IFF (formerly ), Corbion (formerly PURAC Biochem/CSM), and Shoji Foodtech, collectively accounting for the bulk of global output estimated at 11,000-20,000 tons per year as of the early (with recent market data suggesting growth to approximately 25,000 tons by 2023). These companies operate facilities optimized for large-scale production, with capacities scaled to meet demand in food and pharmaceutical sectors. Environmental impacts of lactitol manufacturing are moderated by its use of dairy whey as feedstock, which repurposes an otherwise polluting waste stream and reduces lactose discharge into waterways. However, the process generates from ion-exchange and stages, containing organic residues that necessitate treatment to manage ; hydrogenation byproducts are limited due to high selectivity, but catalyst handling requires protocols to minimize metal leaching. Overall, lifecycle assessments highlight the potential for further gains through advanced and low-energy techniques.

Uses

Food and Beverage Applications

Lactitol functions as a key ingredient in and beverage formulations, offering moderate sweetness equivalent to 30-40% that of , which allows it to contribute bulk without overpowering flavor profiles. This lower relative sweetness often necessitates blending with high-intensity sweeteners, such as or , to achieve desired taste levels in reduced-sugar products while maintaining volume and texture similar to -based formulations. Its caloric contribution of 2 kcal/g—half that of at 4 kcal/g—supports the development of lower-calorie options without fully compromising sensory attributes. As a bulking agent, lactitol excels in sugar-free confections and baked goods, providing structure and in products like chocolates, ice creams, and cookies where it prevents undesirable that can occur with other polyols. In gums and hard candies, it delivers a smooth texture and extended , enabling manufacturers to produce sugar-free variants that mimic traditional sweets. These applications leverage lactitol's solubility and stability under processing conditions, such as heating in or freezing in desserts, to ensure consistent product quality. In beverages and other liquid formulations, lactitol aids in calorie reduction while contributing to and body, particularly in low-sugar soft drinks and flavored waters. Its non-glycemic nature further aligns with formulations targeting calorie-conscious consumers, though detailed physiological impacts are addressed elsewhere. Synergistically, lactitol works with humectants like in low-fat dairy items, such as yogurts, to retain moisture and prevent syneresis, enhancing creaminess in reduced-fat versions. Regulatory frameworks permit lactitol's inclusion in "sugar-free" labeling for products where it replaces , provided total sugars remain below specified thresholds, driving its adoption amid rising demand for low-calorie and diabetic-friendly foods. This trend reflects broader consumer preferences for polyol-based alternatives in and snacks, promoting healthier indulgence options.

Pharmaceutical and Medical Uses

Lactitol serves as an osmotic laxative primarily for the treatment of chronic idiopathic (CIC) in adults, drawing water into the intestines to soften stool and promote bowel movements. It was approved by the U.S. in 2020 as an oral solution under the brand name Pizensy, with a typical dosage of 20 grams once daily, which may be reduced to 10 grams for persistent loose stools. Clinical trials have demonstrated its efficacy in increasing the frequency of complete spontaneous bowel movements, with supplementation well tolerated and comparable to in improving symptoms. In pharmaceutical formulations, lactitol functions as an , particularly as a binder in tablets and due to its high in syrups, aiding in without contributing significant calories. Its inclusion in National Formulary monographs supports its use in various prescription medications, such as extended-release tablets. Due to its low of approximately 3, lactitol has negligible effects on blood glucose levels, making it suitable for formulations in low-glycemic medications and supplements targeted at diabetic patients. This property allows its use in therapeutic products for individuals with without exacerbating glycemic control. Clinical studies have explored lactitol's efficacy in bowel preparation for procedures like , where it achieves adequate cleansing comparable to or regimens, with high success rates in overall bowel adequacy. Additionally, as a prebiotic, lactitol modulates the by promoting beneficial bacteria such as and , enhancing gut health and alleviating symptoms in both diabetic and non-diabetic populations. Trials in patients with liver and have shown it increases microbial diversity and supports digestive function.

Other Industrial Applications

Lactitol serves as a in and , helping to retain moisture in formulations such as lotions, moisturizers, and bases. Its hygroscopic nature allows it to maintain both in product packaging and on the skin, contributing to conditioning and overall product stability. In care, lactitol is incorporated into solutions like Hairspa™, a blend with and glycerin, to provide moisturization and soothe irritation while balancing microflora. For oral care, it has been used in and mouthwashes since the to improve without promoting caries, leveraging its non-fermentable properties. Products such as Ecodermine™ utilize lactitol to enhance well-being across dry, moist, and oily areas, including the and intimate regions. Lactitol is employed as a low-calorie additive in , particularly for pets and , to replicate sugar's functionality without elevating glycemic levels or caloric intake. In and diets, it acts as a prebiotic, enhancing short-chain production by cecal microflora and supporting gut health when included at levels up to 15% in feed. Studies in dogs have confirmed its safety at dietary concentrations of 5-15%, with no adverse effects on growth or organ function, making it suitable for formulations aimed at . For weaned pigs, combinations of lactitol with improve feed efficiency and intestinal , promoting better nutrient utilization. Technical applications of lactitol include its use as a precursor in the synthesis of , emulsifiers, and polymers, though adoption remains limited. Lactitol-based have been developed for cleaning formulations, offering effective in detergents due to their and low . In , it serves as a starting material for poly(ether ) hydrogels and rigid foams, providing structural stability and biodegradability. Emerging applications explore lactitol's potential in biodegradable plastics, leveraging its sugar alcohol structure as a renewable platform chemical for eco-friendly polymers. Research indicates it can contribute to the development of sustainable materials like hydrogels and that degrade more readily than petroleum-based alternatives, aligning with efforts to reduce .

Health and Safety

Nutritional Profile

Lactitol, a derived from , provides approximately 2 kcal per gram, significantly less than the 4 kcal per gram of , due to its partial utilization in the body. This lower caloric value arises from minimal absorption in the , where it is not significantly hydrolyzed or taken up, with the majority reaching the colon for fermentation by , contributing to energy through short-chain production. The of lactitol is very low (reported values around 0-3 relative to glucose set at 100), resulting in minimal impact on blood glucose levels or insulin response. This property makes it suitable for applications where blood sugar control is a consideration, as it does not contribute substantially to postprandial glycemic excursions. In terms of sensory and functional attributes, lactitol exhibits a intensity of 0.3 to 0.4 times that of , providing a mild, clean taste profile similar to table sugar. As a bulking agent, it offers volume and texture comparable to sucrose, allowing for direct 1:1 replacement in formulations without altering product structure significantly. Lactitol demonstrates low digestibility in the upper , with negligible hydrolysis by intestinal enzymes and virtually no absorption as an intact molecule. Instead, 90-100% passes to the , where it is fermented by colonic bacteria, yielding metabolites that provide partial energy recovery. For nutrient labeling purposes, lactitol is classified as a and included in the total carbohydrates declaration on food labels, calculated at 2 kcal/g. However, it is exempt from inclusion in the "added sugars" category under regulations such as those from the FDA, distinguishing it from caloric sweeteners like .

Physiological Effects

Lactitol, a derived from , is minimally absorbed in the and primarily reaches the colon intact, where it undergoes by . This process yields (SCFAs) such as acetate, propionate, and butyrate, which contribute to energy provision for colonocytes and modulation of gut pH. In the colon, lactitol's osmotic properties draw water into the lumen, softening stool and promoting ; at doses exceeding 20 g per day, it exerts a mild effect in healthy individuals by increasing stool frequency and weight without significant disruption to normal bowel function. Gastrointestinal tolerance varies among individuals, with sensitive persons potentially experiencing or due to gas production from incomplete , though these effects are generally mild and dose-dependent. In terms of dental health, lactitol is non-fermentable by common oral bacteria such as , thereby limiting acid production and plaque formation that lead to enamel demineralization. Clinical and studies demonstrate that replacing with lactitol in diets or confections significantly reduces caries risk, positioning it as a non-cariogenic suitable for oral health maintenance. Metabolically, lactitol exhibits a very low (reported values around 0-3), resulting in negligible postprandial blood glucose or insulin elevations, making it appropriate for as it avoids the spikes associated with . Its partial absorption (around 35-40% caloric value) supports stable energy intake without contributing to . Lactitol demonstrates prebiotic potential by selectively stimulating the growth of beneficial gut bacteria, particularly Bifidobacterium species, which enhances diversity and supports overall colonic health. Human trials indicate that supplementation increases Bifidobacterium abundance, correlating with improved gut barrier function and reduced inflammation markers. This selective favors a balanced , distinguishing lactitol from non-prebiotic polyols.

Regulatory Status and Safety Concerns

Lactitol is affirmed as (GRAS) for use as a direct human food ingredient by the , with affirmation published in the in 1993 following evaluation of its safety data. In the , lactitol is approved as a under the designation E966, permitting its use in various foods at levels consistent with good manufacturing practices, as outlined in Regulation (EC) No 1333/2008. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has established an (ADI) for lactitol of "not specified," indicating no safety concern at levels conforming to current consumption practices, based on toxicological evaluations from 1983. Regarding intake limits, the (EFSA) has noted that lactitol is well tolerated up to approximately 70-90 g per day for adults, beyond which laxative effects may occur due to its osmotic properties in the gut. In line with this, labeling regulations require warnings on products containing 10 g or more of polyols (including lactitol) per serving, stating that "excessive consumption may produce laxative effects," to inform consumers of potential digestive discomfort at high intakes. Safety assessments confirm no evidence of genotoxicity for lactitol, as demonstrated in bacterial mutagenicity tests and in vitro studies on human lymphocytes showing no significant DNA damage at relevant concentrations. Similarly, long-term feeding studies in rats and mice, including 2-year carcinogenicity trials at doses up to 10% of the diet, revealed no tumorigenic effects or increased cancer risk attributable to lactitol. Lactitol is considered safe for use in children and pregnant women when consumed in moderation as part of a balanced diet, with no adverse reproductive or developmental effects observed in animal studies or limited human data; however, individual tolerance should be monitored due to potential gastrointestinal sensitivity. Potential concerns include digestive intolerance, particularly in individuals with (IBS), where lactitol and other polyols may exacerbate symptoms such as and by fermenting in the colon and altering gut motility. Rare allergic reactions have been reported in cases of underlying sensitivity, though lactitol's hydrogenated structure minimizes such risks compared to intact lactose; these incidents are uncommon and typically mild. In the 2020s, reviews by organizations such as EFSA and JECFA have reaffirmed lactitol's safety profile for incorporation into low- and no-sugar products, supporting its role in addressing trends by providing a reduced-calorie bulking agent without compromising overall dietary safety.

History

Discovery and Early Development

Lactitol was first synthesized in by French chemist Senderens through the catalytic of using activated as the catalyst. This pioneering work marked the initial production of lactitol as a , or , derived from the . Senderens' method involved reducing the group of under and temperature, yielding a containing lactitol, though the process was rudimentary and primarily aimed at exploring techniques for carbohydrates. Early research on lactitol in focused on its chemical properties and potential as a nutritive , particularly amid growing interest in polyols during periods of sugar scarcity leading into . Studies during this decade demonstrated that lactitol exhibited a reduced caloric value compared to , attributed to its slower enzymatic in the digestive tract, which limited its complete absorption and . Key publications from this era, such as the work by Melville L. Wolfrom and colleagues, detailed the isolation and of anhydrous lactitol forms, identifying two distinct crystalline variants with melting points around 145–150°C and confirming its as 4-O-β-D-galactopyranosyl-D-glucitol. These efforts built on Senderens' foundational synthesis and highlighted lactitol's stability and solubility characteristics. Pre-commercial development faced significant challenges, including low yields and impure products from early laboratory-scale s, primarily due to the instability of catalysts and side reactions like of under reaction conditions. Improvements in catalyst technology, such as the introduction of in the mid-1920s, helped mitigate these issues by enhancing selectivity and reducing byproduct formation, though yields remained below 50% in initial setups. Lactitol's development paralleled that of other polyols, such as and , which were similarly produced via of and during the same period, positioning polyols as viable alternatives in carbohydrate chemistry research.

Commercialization and Modern Uses

Commercial production of lactitol began in the , primarily as a bulk sweetener for low-calorie foods, with early industrial-scale focused on processes derived from . Companies such as played a key role in scaling up production, introducing lactitol-based products like sweeteners and laxatives under brands such as OsmoAid, while contributed through its expertise in sugar-derived polyols. This marked the transition from laboratory synthesis in the early to widespread commercial availability, enabling its integration into , , and pharmaceutical formulations. The 1990s saw significant market growth driven by the popularity of low-carb diets and rising prevalence, positioning lactitol as a suitable alternative to due to its lower caloric content and minimal impact on blood glucose levels. By the , expansion into pharmaceutical applications, particularly as an osmotic , further boosted demand, with products targeting chronic and . Key regulatory milestones included the U.S. FDA granting (GRAS) status in 1993, affirming its safety for food use, and approval as a (E966) in 1994, facilitating broader market access. By the , lactitol had integrated into global supply chains, supported by advancements in production efficiency and . As of 2025, global annual production of lactitol is estimated at approximately 20,000 metric tons, with the ingredient utilized in over 50 countries across , beverage, and pharmaceutical sectors. The market continues to evolve, with post-2020 trends reflecting increased demand for plant-based and functional foods, where lactitol serves as a prebiotic and in alternatives, sugar-free , and items. This growth aligns with consumer preferences for -oriented products that support gut health and reduced sugar intake.

References

  1. https://go.drugbank.com/drugs/DB12942
  2. https://www.intechopen.com/chapters/73028
  3. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/lactitol
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/211281s000lbl.pdf
  5. https://www.fda.gov/food/generally-recognized-safe-gras
  6. https://pubchem.ncbi.nlm.nih.gov/compound/Lactitol
  7. https://www.mtoz-biolabs.com/lactitol-analysis-service.html
  8. https://pubchem.ncbi.nlm.nih.gov/compound/beta-Lactose
  9. https://openprairie.sdstate.edu/dairy_pubdb/2203/
  10. https://www.cabidigitallibrary.org/doi/pdf/10.5555/20183195946
  11. https://www.chemicalbook.com/ChemicalProductProperty_EN_CB5363096.htm
  12. https://www.drugfuture.com/chemdata/lactitol.html
  13. https://www.chembk.com/en/chem/lactitol
  14. https://polyols.org/learn-the-label/lactitol/
  15. https://www.sciencedirect.com/science/article/abs/pii/S1385894707005244
  16. https://patents.google.com/patent/US6090429A/en
  17. https://www.sciencedirect.com/science/article/pii/S2772753X24000388
  18. https://pubchem.ncbi.nlm.nih.gov/compound/lactitol
  19. https://www.sciencedirect.com/science/article/pii/S0924224418306940
  20. https://dataintelo.com/report/global-lactitol-market
  21. https://www.imarcgroup.com/lactitol-manufacturing-plant-project-report
  22. https://caloriecontrol.org/lactitol/
  23. https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-101/subpart-A/section-101.9
  24. https://www.govinfo.gov/content/pkg/FR-1996-08-23/pdf/96-21481.pdf
  25. https://www.fda.gov/consumers/consumer-updates/how-sweet-it-all-about-sweeteners
  26. https://www.fda.gov/food/food-additives-petitions/aspartame-and-other-sweeteners-food
  27. https://www.researchgate.net/publication/23987610_Technological_and_Functional_Applications_of_Low-Calorie_Sweeteners_from_Lactic_Acid_Bacteria
  28. https://www.accessdata.fda.gov/scripts/InteractiveNutritionFactsLabel/assets/InteractiveNFL_SugarAlcohols_October2021.pdf
  29. https://pmc.ncbi.nlm.nih.gov/articles/PMC4103919/
  30. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/211281Orig1s000ChemR.pdf
  31. https://www.drugs.com/inactive/lactitol-52.html
  32. https://www.diabetes.co.uk/sweeteners/lactitol.html
  33. https://www.sciencepublishinggroup.com/article/10.11648/j.ijg.20200402.16
  34. https://pubmed.ncbi.nlm.nih.gov/32483935/
  35. https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2021.762930/full
  36. https://incibeauty.com/en/ingredients/11920-lactitol
  37. https://www.ulprospector.com/en/na/PersonalCare/Detail/1240/44157/Hairspa
  38. https://www.crodabeauty.com/en-gb/products/product/2978-ecodermine
  39. https://patents.google.com/patent/US4760055A/en
  40. https://pubmed.ncbi.nlm.nih.gov/8558313/
  41. https://journals.sagepub.com/doi/pdf/10.3109/10915819209141500
  42. https://www.researchgate.net/publication/273977251_Effect_of_lactitol_lactic_acid_bacteria_or_their_combinations_synbiotic_on_intestinal_proteolysis_in_vitro_and_on_feed_efficiency_in_weaned_pigs
  43. https://www.sciencedirect.com/science/article/am/pii/S0924224418306940
  44. https://www.researchgate.net/publication/12241288_Lactitol-Based_Polyether_polyol_Hydrogels_for_Controlled_Release_Chemical_and_Drug_Delivery_Systems
  45. https://www.sciencedirect.com/science/article/abs/pii/S0924224418306940
  46. https://pmc.ncbi.nlm.nih.gov/articles/PMC4896914/
  47. https://pubmed.ncbi.nlm.nih.gov/9094877/
  48. https://www.federalregister.gov/documents/2016/05/27/2016-11867/food-labeling-revision-of-the-nutrition-and-supplement-facts-labels
  49. https://pmc.ncbi.nlm.nih.gov/articles/PMC492322/
  50. https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2015.4252
  51. https://pmc.ncbi.nlm.nih.gov/articles/PMC5093271/
  52. https://www.federalregister.gov/documents/2007/09/17/E7-18196/food-labeling-health-claims-dietary-noncariogenic-carbohydrate-sweeteners-and-dental-caries
  53. https://pubmed.ncbi.nlm.nih.gov/2649439/
  54. https://www.drugs.com/inactive/lactitol-monohydrate-432.html
  55. https://www.researchgate.net/publication/250058178_Lactitol_an_emerging_prebiotic_Functional_properties_with_a_focus_on_digestive_health
  56. https://pubmed.ncbi.nlm.nih.gov/3552029/
  57. https://pubmed.ncbi.nlm.nih.gov/38060281/
  58. https://journals.sagepub.com/doi/10.3109/10915819209141499
  59. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/211281s001lbl.pdf
  60. https://pmc.ncbi.nlm.nih.gov/articles/PMC4944381/
  61. https://www.rxlist.com/lactitol/generic-drug.htm
  62. https://pubs.acs.org/doi/10.1021/ja01270a020
  63. https://www.nutritionaloutlook.com/view/danisco-share-new-consumer-research-fiber-supplyside-west
  64. https://www.archivemarketresearch.com/reports/lactitol-monohydrate-371634
  65. https://www.linkedin.com/pulse/north-america-lactitol-cas-585-86-4-market-application-olhsc/
  66. https://www.360iresearch.com/library/intelligence/lactitol
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