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Α-Pyrrolidinohexiophenone
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Α-Pyrrolidinohexiophenone
α-Pyrrolidinohexiophenone
Clinical data
Routes of
administration
Oral, intranasal, vaporization, intravenous, rectal, sublingual, subcutaneous
Legal status
Legal status
Identifiers
  • (RS)-1-Phenyl-2-(pyrrolidin-1-yl)hexan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H23NO
Molar mass245.366 g·mol−1
3D model (JSmol)
  • C1(=CC=CC=C1)C(C(CCCC)N2CCCC2)=O
  • InChI=1S/C16H23NO/c1-2-3-11-15(17-12-7-8-13-17)16(18)14-9-5-4-6-10-14/h4-6,9-10,15H,2-3,7-8,11-13H2,1H3
  • Key:KYIJLDDXQWBNGX-UHFFFAOYSA-N

α-Pyrrolidinohexiophenone (α-PHP, A-PHP, Aphp, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s[2] which has been reported as a novel designer drug.[3][4][5][6][7]

Similar chemical compounds

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α-Pyrrolidinohexiophenone is a longer chain homologue of α-PVP, having an extra carbon on the alkyl side chain. Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann[8]) of the National Institute on Drug Abuse stated: "alpha-PHP might be even more potent than alpha-PVP"; this statement is based on laboratory tests of chemical reactivity.[9]

Pyrovalerone is a structural isomer of alpha-PHP.[10]

Legality

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The President of the Republic of Italy classified cathinone and all structurally derived analogues (including pyrovalerone analogues) as narcotics in January 2012.[11][12]

Sweden's public health agency suggested to classify α-PHP as narcotic on June 1, 2015.[13]

As of October 2015, α-PHP is a controlled substance in China.[14]

In December 2019, the UNODC announced scheduling recommendations placing Alpha-PHP into Schedule II.[15]

As of 29 October 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances.[16]

In the US, a-PHP is a Schedule I controlled substance as of 2022.[17]

See also

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References

[edit]
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