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Cloforex
Cloforex
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Chemical compound
Pharmaceutical compound
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| Clinical data | |
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| Trade names | Frenapyl, Lipociden, Oberex, Vidipon, Zeisin |
| Other names | Carbamic acid, N-[2-(4-chlorophenyl)-1,1-dimethylethyl]-, ethyl ester |
| Routes of administration | Oral |
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| Identifiers | |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.034.659  |
| Chemical and physical data | |
| Formula | C13H18ClNO2 |
| Molar mass | 255.74 g·mol−1 |
| 3D model (JSmol) | |
| Melting point | 89 °C (192 °F) |
| Boiling point | 52.75 °C (126.95 °F) |
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Cloforex (Oberex) is an anorectic of the amphetamine class.[1] It is a prodrug to chlorphentermine.[2] It never became a mass produced drug in part due to the side effects found in mice. Mice who consumed 75 mg of cloforex a day experienced weight loss along with pulmonary hypertension and hair loss.[3]
- ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
- ^ Dreyfuss J, Zimmerberg HY, Schreiber EC (1971). "Drug Metabolism.". In Cain CK (ed.). Annual Reports in Medicinal Chemistry. Vol. 6. Boston: Academic Press. pp. 205–214. doi:10.1016/S0065-7743(08)60975-6. ISBN 0-12-040506-7.
- ^ Woodward SC (1981). "Induction and reversal of pulmonary lipid histiocytosis in rats following oral administration of anorectics cloforex and chlorphentermine". Journal of Toxicology and Environmental Health. 7 (3–4): 569–583. Bibcode:1981JTEH....7..569W. doi:10.1080/15287398109530002. ISSN 0098-4108. PMID 7197305.
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