Isaiah 6 is the sixth chapter of the Book of Isaiah in the Hebrew Bible or the Old Testament of the Christian Bible. This book contains the prophecies attributed to the prophet Isaiah, and is one of the Books of the Prophets. It records the calling of Isaiah to be the messenger of God to the people of Israel.

The original text was written in Hebrew language. This chapter is divided into 13 verses.

Some early manuscripts containing the text of this chapter in Hebrew are of the Masoretic Text tradition, which includes the Codex Cairensis (895), the Petersburg Codex of the Prophets (916), Aleppo Codex (10th century), Codex Leningradensis (1008).

Fragments containing parts of this chapter were found among the Dead Sea Scrolls (3rd century BCE or later):

There is also a translation into Koine Greek known as the Septuagint, made in the last few centuries BCE. Extant ancient manuscripts of the Septuagint version include Codex Vaticanus (B; ${\displaystyle {\mathfrak {G}}}$^B; 4th century), Codex Sinaiticus (S; BHK: ${\displaystyle {\mathfrak {G}}}$^S; 4th century), Codex Alexandrinus (A; ${\displaystyle {\mathfrak {G}}}$^A; 5th century) and Codex Marchalianus (Q; ${\displaystyle {\mathfrak {G}}}$^Q; 6th century).

In Jewish prayer, the entire Isaiah 6 is part of the Haftara on the Shabbat when the parasha of Yitro, which includes the Ten Commandments, is read from the Torah scroll.

The date of the death of Uzziah has been estimated as around 740 BCE. Archaeologist William F. Albright dated Uzziah's reign to 783–742 BCE.

This verse is repeated several times in daily Jewish services, including the Kedushah prayer during the repetition of the Amidah, and is part of the Sanctus in Christian Eucharistic Prayer.