TAL1

TAL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YPA, 2YPB
Identifiers
Aliases	TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor
External IDs	OMIM: 187040; MGI: 98480; HomoloGene: 2400; GeneCards: TAL1; OMA:TAL1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	47,232,225 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	114,928,952 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; monocyte; ; bone marrow; ; right lung; ; endothelial cell; ; blood; ; upper lobe of left lung; ; bone marrow cell; ; buccal mucosa cell; ; epithelium of colon;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; tibiofemoral joint; ; blood; ; human fetus; ; embryo; ; spleen; ; endocardial cushion; ; bone marrow; ; yolk sac; ; genital tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription factor activity; histone deacetylase binding; chromatin binding; transcription cis-regulatory region binding; E-box binding; protein binding; protein heterodimerization activity; enzyme binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	histone deacetylase complex; transcription regulator complex; Lsd1/2 complex; nucleus; nucleoplasm; protein-containing complex;
Biological process	megakaryocyte development; megakaryocyte differentiation; myeloid cell differentiation; cell fate commitment; cell differentiation; regulation of transcription, DNA-templated; regulation of mast cell differentiation; spinal cord association neuron differentiation; positive regulation of protein-containing complex assembly; locomotory behavior; positive regulation of erythrocyte differentiation; regulation of transcription by RNA polymerase II; regulation of stem cell population maintenance; platelet formation; positive regulation of mitotic cell cycle; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; generation of neurons; basophil differentiation; positive regulation of transcription, DNA-templated; multicellular organism development; regulation of cell population proliferation; hematopoietic stem cell differentiation; astrocyte fate commitment; angiogenesis; neuron differentiation; embryonic hemopoiesis; erythrocyte differentiation; definitive hemopoiesis; regulation of myeloid cell differentiation; positive regulation of cell division; hemangioblast cell differentiation; positive regulation of transcription by RNA polymerase II; erythrocyte maturation; regulation of hematopoietic stem cell differentiation; hemopoiesis; transcription by RNA polymerase II; negative regulation of erythrocyte differentiation; positive regulation of protein tyrosine kinase activity; positive regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	6886
	21349
	ENSG00000162367
	ENSMUSG00000028717
	P17542
	P22091
NM_001287347; NM_001290403; NM_001290404; NM_001290405; NM_001290406;
	NM_003189
	NM_011527; NM_001287388
NP_001274276; NP_001277332; NP_001277333; NP_001277334; NP_001277335;
	NP_003180
	NP_001274317; NP_035657
	Wikidata
View/Edit Human	View/Edit Mouse

T-cell acute lymphocytic leukemia protein 1 (i.e. TAL1 but also termed stem cell leukemia/T-cell acute leukemia 1 [i.e. SCL/TAL1]) is a protein that in humans is encoded by the TAL1 gene.^[5]^[6]

The protein encoded by TAL1 is a basic helix-loop-helix transcription factor.

Interactions

TAL1 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000162367 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028717 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. Bibcode:1989PNAS...86.5039F. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.
^ "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".
^ ^a ^b ^c ^d ^e Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.
^ Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
^ ^a ^b Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.
^ ^a ^b Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.
^ ^a ^b Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.
^ Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.
^ Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.
^ Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

External links

TAL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
FactorBook TAL1

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000162367 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028717 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2740341-5] Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (August 1989). "Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma". Proc Natl Acad Sci U S A. 86 (13): 5039–43. Bibcode:1989PNAS...86.5039F. doi:10.1073/pnas.86.13.5039. PMC 297552. PMID 2740341.

[entrez-6] "Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1".

[pmid16407974-7] Goardon N, Lambert JA, Rodriguez P, Nissaire P, Herblot S, Thibault P, Dumenil D, Strouboulis J, Romeo PH, Hoang T (January 2006). "ETO2 coordinates cellular proliferation and differentiation during erythropoiesis". EMBO J. 25 (2): 357–66. doi:10.1038/sj.emboj.7600934. PMC 1383517. PMID 16407974.

[pmid10490830-8] Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). "p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein". Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.

[pmid7568177-9] Osada H, Grutz G, Axelson H, Forster A, Rabbitts TH (October 1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. Bibcode:1995PNAS...92.9585O. doi:10.1073/pnas.92.21.9585. PMC 40846. PMID 7568177.

[pmid8078932-10] Valge-Archer VE, Osada H, Warren AJ, Forster A, Li J, Baer R, Rabbitts TH (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode:1994PNAS...91.8617V. doi:10.1073/pnas.91.18.8617. PMC 44657. PMID 8078932.

[pmid7957052-11] Wadman I, Li J, Bash RO, Forster A, Osada H, Rabbitts TH, Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia". EMBO J. 13 (20): 4831–9. doi:10.1002/j.1460-2075.1994.tb06809.x. PMC 395422. PMID 7957052.

[pmid10688671-12] Huang S, Brandt SJ (March 2000). "mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor". Mol. Cell. Biol. 20 (6): 2248–59. doi:10.1128/mcb.20.6.2248-2259.2000. PMC 110841. PMID 10688671.

[pmid12239153-13] Lécuyer E, Herblot S, Saint-Denis M, Martin R, Begley CG, Porcher C, Orkin SH, Hoang T (October 2002). "The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1". Blood. 100 (7): 2430–40. doi:10.1182/blood-2002-02-0568. PMID 12239153.

[pmid8159721-14] Hsu HL, Wadman I, Baer R (April 1994). "Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3181–5. Bibcode:1994PNAS...91.3181H. doi:10.1073/pnas.91.8.3181. PMC 43539. PMID 8159721.

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Hub overview

Root Wikipedia Article

TAL1

Interactions

References

Further reading

External links