Pituitary-specific positive transcription factor 1

POU1F1
Identifiers
Aliases	POU1F1, CPHD1, GHF-1, PIT1, POU1F1a, Pit-1, POU class 1 homeobox 1
External IDs	OMIM: 173110; MGI: 97588; HomoloGene: 259; GeneCards: POU1F1; OMA:POU1F1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	87,276,584 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	65,331,891 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; muscle of thigh; ; striated muscle tissue; ; skeletal muscle tissue; ; gastrocnemius muscle; ; Brodmann area 9; ; right uterine tube; ; mucosa of transverse colon; ; right coronary artery;
	Top expressed in
	female urethra; ; anterior pituitary; ; embryo; ; pars distalis of adenohypophysis; ; bone marrow; ; duodenum; ; urinary bladder; ; ovary;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; transcription corepressor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; chromatin binding; DNA-binding transcription factor activity; transcription factor binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; transcription regulator complex; chromatin;
Biological process	negative regulation of cell population proliferation; somatotropin secreting cell development; adenohypophysis development; positive regulation of inositol trisphosphate biosynthetic process; regulation of insulin-like growth factor receptor signaling pathway; pituitary gland development; regulation of transcription, DNA-templated; cell fate specification; B cell differentiation; positive regulation of cell population proliferation; positive regulation of transcription, DNA-templated; determination of adult lifespan; positive regulation of transcription by RNA polymerase II; positive regulation of multicellular organism growth; nuclear transport; negative regulation of transcription by RNA polymerase II; somatotropin secreting cell differentiation; transcription, DNA-templated; transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	5449
	18736
	ENSG00000064835
	ENSMUSG00000004842
	P28069
	Q00286
	NM_001122757; NM_000306
	NM_008849; NM_001362468
	NP_000297; NP_001116229
	NP_032875; NP_001349397
	Wikidata
View/Edit Human	View/Edit Mouse

POU class 1 homeobox 1, also known as pituitary-specific positive transcription factor 1 (PIT1), POU domain, class 1, transcription factor 1 (POU1F1) and growth hormone factor 1 (GHF1), is a transcription factor for growth hormone encoded by the gene POU1F1.^[5]^[6]

Function

PIT1 is part of the POU family of transcription factors.^[7] It is expressed by somatotrophic cells,^[8] as well as thyrotrophs^[9] and lactotrophs^[10] of the anterior pituitary gland. It contains a C-terminal domain for transactivation.^[9] Another domain is DNA binding—its C-terminal portion is homologous to the homeodomain consensus,^[8] common to many genes involved in development, while the other portion is POU specific, affords PIT1 specificity in its transcriptional activation of the prolactin and growth hormone genes and is involved in protein-protein interactions.^[9] Activity on thyroid stimulating hormone-beta expression is also known for PIT1.^[9]

Interactions

Pituitary-specific positive transcription factor 1 has been shown to interact with GATA2^[11] and PITX1.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000064835 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004842 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: POU1F1 POU class 1 homeobox 1 [ Homo sapiens (human) ]". National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 2 January 2024.
^ "Symbol report for POU1F1". HGNC. HUGO Gene Nomenclature Committee. 2023. Retrieved 2 January 2024.
^ O'Neill, Marla J.F. (22 September 2021) [Originally authored by Victor A. McKusick on 13 January 1989]. "POU DOMAIN, CLASS 1, TRANSCRIPTION FACTOR 1; POU1F1". Online Mendelian Inheritance in Man. Retrieved 3 January 2024.
^ ^a ^b Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–518. doi:10.1016/0092-8674(88)90037-2. PMID 2902927. S2CID 26376487.
^ ^a ^b ^c ^d Vallette-Kasic S, Pellegrini-Bouiller I, Sampieri F, Gunz G, Diaz A, Radovic S, Enjalbert A, Brue T (2001). "Combined Pituitary Hormone Deficiency due to the F135C Human Pit-1 (Pituitary-Specific Factor 1) Gene Mutation: Functional and Structural Correlates". Molecular Endocrinology. 15 (3): 411–420. doi:10.1210/mend.15.3.0601. PMID 11222742.
^ Cohen LE, Wondisford FE, Radovick S (1996). "Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin". Endocrinology and Metabolism Clinics of North America. 25 (3): 523–540. doi:10.1016/s0889-8529(05)70339-x. PMID 8879985.
^ Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888. S2CID 15737684.
^ Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (July 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. Bibcode:1996PNAS...93.7706S. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

External links

PIT1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Transcription+Factor+Pit-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000064835 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004842 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ncbi-5] "Entrez Gene: POU1F1 POU class 1 homeobox 1 [ Homo sapiens (human) ]". National Library of Medicine, National Center for Biotechnology Information. 23 November 2023. Retrieved 2 January 2024.

[6] "Symbol report for POU1F1". HGNC. HUGO Gene Nomenclature Committee. 2023. Retrieved 2 January 2024.

[7] O'Neill, Marla J.F. (22 September 2021) [Originally authored by Victor A. McKusick on 13 January 1989]. "POU DOMAIN, CLASS 1, TRANSCRIPTION FACTOR 1; POU1F1". Online Mendelian Inheritance in Man. Retrieved 3 January 2024.

[bodner1988-8] Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M (1988). "The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein". Cell. 55 (3): 505–518. doi:10.1016/0092-8674(88)90037-2. PMID 2902927. S2CID 26376487.

[vallettekasic2001-9] Vallette-Kasic S, Pellegrini-Bouiller I, Sampieri F, Gunz G, Diaz A, Radovic S, Enjalbert A, Brue T (2001). "Combined Pituitary Hormone Deficiency due to the F135C Human Pit-1 (Pituitary-Specific Factor 1) Gene Mutation: Functional and Structural Correlates". Molecular Endocrinology. 15 (3): 411–420. doi:10.1210/mend.15.3.0601. PMID 11222742.

[10] Cohen LE, Wondisford FE, Radovick S (1996). "Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin". Endocrinology and Metabolism Clinics of North America. 25 (3): 523–540. doi:10.1016/s0889-8529(05)70339-x. PMID 8879985.

[pmid10367888-11] Dasen JS, O'Connell SM, Flynn SE, Treier M, Gleiberman AS, Szeto DP, Hooshmand F, Aggarwal AK, Rosenfeld MG (May 1999). "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 (5): 587–98. doi:10.1016/S0092-8674(00)80770-9. PMID 10367888. S2CID 15737684.

[pmid8755540-12] Szeto DP, Ryan AK, O'Connell SM, Rosenfeld MG (July 1996). "P-OTX: a PIT-1-interacting homeodomain factor expressed during anterior pituitary gland development". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7706–10. Bibcode:1996PNAS...93.7706S. doi:10.1073/pnas.93.15.7706. PMC 38811. PMID 8755540.

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