A desktop computer, often abbreviated as desktop, is a personal computer designed for regular use at a stationary location on or near a desk (as opposed to a portable computer) due to its size and power requirements. The most common configuration has a case that houses the power supply, motherboard (a printed circuit board with a microprocessor as the central processing unit, memory, bus, certain peripherals and other electronic components), disk storage (usually one or more hard disk drives, solid-state drives, optical disc drives, and in early models floppy disk drives); a keyboard and mouse for input; and a monitor, speakers, and, often, a printer for output. The case may be oriented horizontally or vertically and placed either underneath, beside, or on top of a desk.

Desktop computers with their cases oriented vertically are referred to as towers. As the majority of cases offered since the mid 1990s are in this form factor, the term desktop has been retronymically used to refer to modern cases offered in the traditional horizontal orientation.

Prior to the widespread use of microprocessors, a computer that could fit on a desk was considered remarkably small; the type of computers most commonly used were minicomputers, which, despite the name, were rather large and were "mini" only compared to the so-called "big iron". Early computers, and later the general purpose high throughput "mainframes", took up the space of a whole room. Minicomputers, on the contrary, generally fit into one or a few refrigerator-sized racks, or, for the few smaller ones, built into a fairly large desk, not put on top of it.

It was not until the 1970s when fully programmable computers appeared that could fit entirely on top of a desk. 1970 saw the introduction of the Datapoint 2200, a "smart" computer terminal complete with keyboard and monitor, was designed to connect with a mainframe computer but that did not stop owners from using its built-in computational abilities as a stand-alone desktop computer. The HP 9800 series, which started out as programmable calculators in 1971 but was programmable in BASIC by 1972, used a smaller version of a minicomputer design based on ROM memory and had small one-line LED alphanumeric displays and displayed graphics with a plotter. The Wang 2200 of 1973 had a full-size cathode-ray tube (CRT) and cassette tape storage. The IBM 5100 in 1975 had a small CRT display and could be programmed in BASIC and APL. These were generally expensive specialized computers sold for business or scientific uses.

Apple II, TRS-80 and Commodore PET were first generation personal home computers launched in 1977, which were aimed at the consumer market – rather than businessmen or computer hobbyists. Byte magazine referred to these three as the "1977 Trinity" of personal computing. Throughout the 1980s and 1990s, desktop computers became the predominant type, the most popular being the IBM PC and its clones, followed by the Apple Macintosh, with the third-placed Commodore Amiga having some success in the mid-1980s but declining by the early 1990s.

Early personal computers, like the original IBM Personal Computer, were enclosed in a "desktop case", horizontally oriented to have the display screen placed on top, thus saving space on the user's actual desk, although these cases had to be sturdy enough to support the weight of CRT displays that were widespread at the time. Over the course of the 1990s, desktop cases gradually became less common than the more-accessible tower cases that may be located on the floor under or beside a desk rather than on a desk. Not only do these tower cases have more room for expansion, they have also freed up desk space for monitors which were becoming larger every year. Desktop cases, particularly the compact form factors, remain popular for corporate computing environments and kiosks. Some computer cases can be interchangeably positioned either horizontally (desktop) or upright (mini-tower).

Influential games such as Doom and Quake during the 1990s had pushed gamers and enthusiasts to frequently upgrade to the latest CPUs and graphics cards (3dfx, ATI, and Nvidia) for their desktops (usually a tower case) in order to run these applications, though this has slowed since the late 2000s as the growing popularity of Intel integrated graphics forced game developers to scale back. Creative Technology's Sound Blaster series were a de facto standard for sound cards in desktop PCs during the 1990s until the early 2000s, when they were reduced to a niche product, as OEM desktop PCs came with sound boards integrated directly onto the motherboard.

While desktops have long been the most common configuration for PCs, by the mid-2000s the growth shifted from desktops to laptops. Laptops had long been produced by contract manufacturers based in Asia, such as Foxconn, and this shift led to the closure of the many desktop assembly plants in the United States by 2010. Another trend around this time was the increasing proportion of inexpensive base-configuration desktops being sold, hurting PC manufacturers such as Dell whose build-to-order customization of desktops relied on upselling added features to buyers.