Interculturalism is a political movement that supports cross-cultural dialogue and challenging self-segregation tendencies within cultures. Interculturalism involves moving beyond mere passive acceptance of multiple cultures existing in a society and instead promotes dialogue and interaction between cultures. Interculturalism is often used to describe the set of relations between indigenous and western ideals, grounded in values of mutual respect.

Interculturalism has arisen in response to criticisms of existing policies of multiculturalism, such as criticisms that such policies had failed to create inclusion of different cultures within society, but instead have divided society by legitimizing segregated separate communities that have isolated themselves and accentuated their specificity. It is based on the recognition of both differences and similarities between cultures. It has addressed the risk of the creation of absolute relativism within postmodernity and in multiculturalism. Interculturalism has been used as a tool of Native American and indigenous rights activists to achieve rights and recognition.

Philosopher Martha Nussbaum in her work Cultivating Humanity, describes interculturalism as involving "the recognition of common human needs across cultures and of dissonance and critical dialogue within cultures" and that interculturalists "reject the claim of identity politics that only members of a particular group have the ability to understand the perspective of that group". Anthropologist Joanne Rappaport describes interculturalism as consisting of three main threads: a method of connection, a political philosophy aimed at creating utopian indigenous citizenship, and a challenge to traditional ethnography. Rappaport discusses the importance of interculturalism in the Colombian Indigenous movement for human rights and recognition.

Interculturalism has been included in different national constitutions across Latin America, including Bolivia, Ecuador (2008), Brazil, and across Europe. Colombia includes the concept of multiculturalism and pluriethnic citizenship in its 1991 constitution. The Ecuadorian constitution has been described as in between both multiculturalism and interculturalism.

The United Nations' agency UNESCO adopted the Convention on the Protection and Promotion of the Diversity of Cultural Expressions in 2005, which declares support for interculturalism. In Germany, all universities are required to have a section on intercultural competence in their social work programs, that involves students being able to be open to listen and communicate with people of different cultural backgrounds, have knowledge of the backgrounds of cultural groups, knowledge of existing stereotypes and prejudices involving cultural groups, and other criteria. Salman Cheema, the Head of Marketing and Communications of the British Council, in an article titled "From Multiculturalism to Interculturalism – A British perspective", spoke of an event co-hosted by the British Council and Canada's Institute for Research on Public Policy (IRPP) in Montreal, Quebec, Canada on April 11, 2013, interculturalist advocate Phil Wood declared that multiculturalism has faced serious problems that need to be resolved through interculturalism, and rejected those opponents of multiculturalism who seek to restore a pre-multiculturalist monoculturalist society. Several days later in Montreal, the New Democratic Party of Canada (NDP) declared support for interculturalism in the preamble of its constitution adopted its federal convention held in Montreal on April 14, 2013.

Intercultural health applies the concepts of interculturalism to health settings. It involves conceptualizing health itself as part of a broader cultural framework. Intercultural health defines what counts as "health" as outside purely biomedicine. In many cases, intercultural health is an approach that seeks to reduce gaps between indigenous health and biomedical health systems. Indigenous health systems, sometimes grouped in with alternative medicine, often involve different kinds of healers, plant medicine techniques, holistic medicine, and indigenous knowledge that has been passed down through generations. Intercultural health systems often state the goal of creating better health outcomes in indigenous communities and generating mutual respect between biomedical practitioners and indigenous healers.

The implementation of intercultural health practices is associated with the project of decentralizing health systems, especially in Latin America. Ecuadorian epidemiologist and physician Jaime Breilh is a proponent of intercultural health for its benefits on population health. Structural violence, a term developed by American medical anthropologist and physician Paul Farmer, describes a lack of available health care as a form of violence. Supporters of intercultural health care models cite addressing structural violence as a goal. The goal of many intercultural health models is to treat indigenous knowledge with the same respect as biomedicine. Intercultural health models have been associated with improved health outcomes in indigenous communities.

Effective intercultural health projects involve buy-in from all cultures represented. Anthropologist Catherine Walsh describes the concept of "critical interculturality." She defines this as using indigenous concepts to question the existing structure and advance epistemic change. This type of change requires what anthropologist Linda Tuhiwai Smith calls decolonizing methodologies, which call for a reconsideration of what counts as knowledge. There are examples of intercultural health projects that do not fully incorporate indigenous methodologies and instead continue to perpetuate the western hegemonic order.