Amazon has been criticized on many issues, including anti-competitive business practices, its treatment of workers, offering counterfeit or plagiarized products, objectionable content of its books, tax and subsidy deals with governments supplying law enforcement with facial recognition surveillance tools; forming cloud computing partnerships with the CIA; leading customers away from bookshops; adversely impacting the environment; placing a low priority on warehouse conditions for workers; actively opposing unionization efforts; remotely deleting content purchased by Amazon Kindle users; taking public subsidies; seeking to patent its 1-Click technology; engaging in anti-competitive actions and price discrimination; and reclassifying LGBTQ books as adult content. Criticism has also concerned various decisions over whether to censor or publish content such as the WikiLeaks website, works containing libel, anti-LGBT merchandise, and material facilitating dog fighting, cockfighting, or pedophile activities.

An article published by Time in the wake of social media website Parler's termination of service by Amazon Web Service highlights the power companies like Amazon now have over the internet. In December 2011, Amazon faced a backlash from small businesses for running a one-day deal to promote its new Price Check app. Shoppers who used the app to check prices in a brick-and-mortar store were offered a 5% discount to purchase the same item from Amazon. Companies like Groupon, eBay and Taap have countered Amazon's promotion by offering $10 off from its products.

The company has also faced accusations of putting undue pressure on suppliers to maintain and extend its profitability. One effort to squeeze the most vulnerable book publishers was known within the company as the Gazelle Project, after Bezos suggested, according to Brad Stone, "that Amazon should approach these small publishers the way a cheetah would pursue a sickly gazelle." In July 2014, the Federal Trade Commission launched a lawsuit against the company alleging it was promoting in-app purchases to children, which were being transacted without parental consent. In 2019, Amazon banned selling skin-lightening products after pushback from Minnesota health and environmental activists. In 2022, a lawsuit filed by state attorney-general Letitia James was dismissed by the New York state court of appeals. After the COVID-19 pandemic, Amazon faced criticism for complying, under pressure from the Biden Administration, to "reduce the visibility" of books critical of the COVID-19 vaccine, which was revealed after Rep. Jim Jordan (acting on behalf of the House Judiciary Committee) subpoenaed emails between the company and the Biden Administration.

Amazon Prime has been criticized for its vehicles systemically double parking, blocking bike lanes, and otherwise violating traffic laws while dropping off packages, contributing to traffic congestion and endangering other road users.

Jane Friedman discovered six listings of books fraudulently using her name, on Amazon and Goodreads. Amazon and Goodreads resisted removing the fraudulent titles until the author's complaints went viral on social media, in a blog post titled "I Would Rather See My Books Get Pirated Than This (Or: Why Goodreads and Amazon Are Becoming Dumpster Fires)."

In 2024, following years of criticism for providing law enforcement footage in the custody of Ring (a home security company owned by Amazon) without a warrant, Ring has halted this practice. It received cautious praise from privacy-focused organizations such as the Electronic Frontier Foundation for this change.

In February 2025, Sky accused Amazon of not doing enough to prevent the piracy of its sports rights via "jailbroken" Fire Sticks.

Project Nimbus is a contract by which Amazon and Google provide Israel and its military with artificial intelligence, machine learning, and other cloud-computing services. The contract has been criticized by shareholders and employees concerned that the project may lead to abuses of Palestinian human rights in the Israeli–Palestinian conflict. In October 2025, Amazon suspended an employee who posted messages to the company's Slack and wrote a letter to Andy Jassy criticizing Nimbus.