Wildlife refers to undomesticated animals and uncultivated plant species which can exist in their natural habitat, but has come to include all organisms that grow or live wild in an area without being introduced by humans. Wildlife was also synonymous to game, birds and mammals hunted for sport. Wildlife can be found in all ecosystems, both wild and most developed urban areas, forming distinct groups. While the term in popular culture usually refers to animals that are untouched by human existence, most scientists agree that much wildlife is affected by humans. Some wildlife threaten human safety, health, property and quality of life, but many wild animals have value to humans, whether economic, educational, or sentimental.

Humans have historically tended to separate civilization from wildlife in a number of ways, including the legal, social and moral senses. Some animals, however, have adapted to suburban environments. This includes urban wildlife such as feral cats, dogs, mice, and rats. Some religions declare certain animals to be sacred, and in modern times, concern for the natural environment has provoked activists to protest against the exploitation of wildlife for human benefit or entertainment.

The annual international trade may be worth billions of dollars and affects hundreds of millions of individual specimens. Global wildlife populations have decreased significantly, by 68% since 1970, as a result of human activity, with identified causes including overconsumption, population growth, and intensive farming. This is cited as evidence that humans have unleashed a sixth mass extinction event.

Wildlife refers to undomesticated animals and uncultivated plant species which can exist in their natural habitat, but has come to include all organisms that grow or live wild in an area without being introduced by humans. Wildlife was also synonymous to game, birds and mammals hunted for sport. Wildlife can be found in all ecosystems. Deserts, plains, grasslands, woodlands, forests, and other areas including the most developed urban areas, all have distinct forms of wildlife. While the term in popular culture usually refers to animals that are untouched by human behavior, most scientists agree that much wildlife is affected by it.

Humans have historically tended to separate civilization from wildlife in a number of ways, including the legal, social and moral senses. Some animals, however, have adapted to suburban environments. This includes urban wildlife such as feral cats, dogs, mice, and rats. Some religions declare certain animals to be sacred, and in modern times, concern for the natural environment has provoked activists to protest against the exploitation of wildlife for human benefit or entertainment.

Different countries have various legal definitions.

Wildlife trade refers to the exchange of products derived from non-domesticated animals or plants usually extracted from their natural environment or raised under controlled conditions. It can involve the trade of living or dead individuals, tissues such as skins, bones or meat, or other products. Legal wildlife trade is regulated by the United Nations' Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), which currently has 184 member countries called Parties. Illegal wildlife trade is widespread and constitutes one of the major illegal economic activities, comparable to the traffic of drugs and weapons.

Despite various regional legal definitions for "wildlife", according to CITES, the annual international wildlife trade is likely worth billions of dollars and affects hundreds of millions of individual animals and plants.